| Gene Symbol |
Frs2
|
| Entrez Gene |
327826
|
| Alt Symbol |
4732458E18, C330018A15Rik, Frs2alpha, SNT1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
fibroblast growth factor receptor substrate 2
|
| Other Description |
FGFR substrate 2|FGFR-signaling adaptor SNT|FRS2-alpha|SNT-1|suc1-associated neurotrophic factor target 1
|
| Swissprots |
Q8C180
|
| Accessions |
EDL21826 EDL21827 EDL21828 Q8C180 AK028813 BAC26132 AK031984 AK049265 AK138144 BAE23560 AK163442 BC043109 AAH43109 BC055334 AAH55334 NM_177798 NP_808466
|
| Function |
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:11390647, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:9182757, ECO:0000269|PubMed:9632781}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:8780727}; Lipid-anchor {ECO:0000269|PubMed:8780727}.
|
| Tissue Specificity |
Ubiquitous. Expression is highest in brain, kidney, lung and testis. {ECO:0000269|PubMed:9182757}.
|
| Top Pathways |
Neurotrophin signaling pathway, Proteoglycans in cancer
|