Frs2

Gene Symbol	Frs2
Entrez Gene	327826
Alt Symbol	4732458E18, C330018A15Rik, Frs2alpha, SNT1
Species	Mouse
Gene Type	protein-coding
Description	fibroblast growth factor receptor substrate 2
Other Description	FGFR substrate 2|FGFR-signaling adaptor SNT|FRS2-alpha|SNT-1|suc1-associated neurotrophic factor target 1
Swissprots	Q8C180
Accessions	EDL21826 EDL21827 EDL21828 Q8C180 AK028813 BAC26132 AK031984 AK049265 AK138144 BAE23560 AK163442 BC043109 AAH43109 BC055334 AAH55334 NM_177798 NP_808466
Function	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:11390647, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:9182757, ECO:0000269|PubMed:9632781}.
Subcellular Location	Membrane {ECO:0000269|PubMed:8780727}; Lipid-anchor {ECO:0000269|PubMed:8780727}.
Tissue Specificity	Ubiquitous. Expression is highest in brain, kidney, lung and testis. {ECO:0000269|PubMed:9182757}.
Top Pathways	Neurotrophin signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse FRS2 Protein - abx066621 from Abbexa Category Protein Source E.coli Species Mouse

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) - RPC063Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Fibroblast growth factor receptor substrate 2(Frs2) - CSB-YP009004MO CSB-EP009004MO CSB-BP009004MO CSB-MP009004MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Fibroblast Growth Factor Receptor Substrate 2 (FRS2) - RPU141460 from Biomatik Category Protein Prices $242.00, $484.00, $726.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Recombinant Mouse FRS2 Protein - FRS2-6048M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Fibroblast growth factor receptor substrate 2 (Frs2), Recombinant Protein - MBS1434221 from MyBioSource Category Protein Prices $1,295.00, $1,295.00, $1,515.00, $1,515.00, $2,130.00, $2,130.00, $2,595.00, $2,595.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) - RPU41460 from Biomatik Category Protein Prices $194.00, $396.00, $605.00, $721.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

FRS2 Recombinant Protein (OPCD03308) - OPCD03308 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

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