FOXO1

Gene Symbol	FOXO1
Entrez Gene	2308
Alt Symbol	FKH1, FKHR, FOXO1A
Species	Human
Gene Type	protein-coding
Description	forkhead box O1
Other Description	forkhead box protein O1|forkhead box protein O1A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma
Swissprots	Q6NSK6 Q5VYC7 O43523 Q12778
Accessions	AAC50342 AAC50343 EAX08627 Q12778 AF032885 AAC39591 AK310511 BC021981 AAH21981 BC070065 AAH70065 BT007455 AAP36123 BX648278 U02310 AAA03629 U36922 XM_011535008 XP_011533310 XM_011535009 XP_011533311 XM_011535010 XP_011533312 XR_941536 NM_002015 NP_002006
Function	Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and S
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:Q9R1E0}. Nucleus {ECO:0000250|UniProtKB:Q9R1E0}. Note=Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation. {ECO:0000250}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:9479491}.
Top Pathways	Insulin signaling pathway, Prostate cancer, AMPK signaling pathway, Glucagon signaling pathway, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FOXO1A (phospho S256) peptide - ab27886 from Abcam Category Peptide

Human FOXO1A peptide - ab27887 from Abcam Category Peptide

FOXO1 / FKHR Blocking Peptide - LS-E10765 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO1 / FKHR Antibody Blocking Peptide - LS-E8352 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO1 / FKHR Antibody Blocking Peptide - LS-E30947 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FOXO1 / FKHR Antibody Blocking Peptide - LS-E11614 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO1 / FKHR Antibody Blocking Peptide - LS-E11221 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO1 / FKHR Antibody Blocking Peptide - LS-E13668 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO1 / FKHR Antibody Blocking Peptide - LS-E26313 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FoxO1/FKHR Protein - H00002308-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FoxO1/FKHR Peptide - NBP1-77172PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

FKHR-Antibody-Center-D469-Blocking-Peptide - BP6644c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOXO1 blocking peptide - GTX89102-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

FOXO1 peptide - orb217294 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Monkey

FOXO1 (phospho-Ser319) Blocking Peptide - abx062624 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey, Pig

FOXO1 Blocking Peptide - abx062625 from Abbexa Category Peptide Species Human, Bovine, Monkey, Pig

Human FOXO1 Protein - abx066687 from Abbexa Category Protein Source E.coli Species Human

FOXO1A Peptide - AC21-1148-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FOXO1A - H00002308-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FOXO1A - H00002308-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FOXO1A control peptide - AP26218CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

FOXO1 Peptide - 5811P from ProSci Category Peptide Species Human

FOXO1 Peptide - 45-622P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

FOXO1 fusion protein - ag13140 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

FOXO1 fusion protein - Ag13296 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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