| Gene Symbol | CHSY1 |
|---|---|
| Entrez Gene | 22856 |
| Alt Symbol | CHSY, CSS1, ChSy-1, TPBS |
| Species | Human |
| Gene Type | protein-coding |
| Description | chondroitin sulfate synthase 1 |
| Other Description | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1|N-acetylgalactosaminyltransferase II|carbohydrate synthase 1|chondroitin glucuronyltransferase 1|chondroitin glucuronyltransferase II|chondroitin synthase 1|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1 |
| Swissprots | Q9Y2J5 Q86X52 Q7LFU5 Q6UX38 |
| Accessions | EAX02292 Q86X52 AB023207 BAA76834 AB071402 BAB64936 AK075096 AK296943 BAG59492 AL137409 AY358529 AAQ88893 BC046247 AAH46247 BQ007796 XM_006720435 XP_006720498 XM_011521364 XP_011519666 XM_011521365 XP_011519667 NM_014918 NP_055733 |
| Function | Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. {ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:21129727}. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Secreted. |
| Tissue Specificity | Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:12907687}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |