CHSY1

Gene Symbol CHSY1
Entrez Gene 22856
Alt Symbol CHSY, CSS1, ChSy-1, TPBS
Species Human
Gene Type protein-coding
Description chondroitin sulfate synthase 1
Other Description N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1|N-acetylgalactosaminyltransferase II|carbohydrate synthase 1|chondroitin glucuronyltransferase 1|chondroitin glucuronyltransferase II|chondroitin synthase 1|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1
Swissprots Q9Y2J5 Q86X52 Q7LFU5 Q6UX38
Accessions EAX02292 Q86X52 AB023207 BAA76834 AB071402 BAB64936 AK075096 AK296943 BAG59492 AL137409 AY358529 AAQ88893 BC046247 AAH46247 BQ007796 XM_006720435 XP_006720498 XM_011521364 XP_011519666 XM_011521365 XP_011519667 NM_014918 NP_055733
Function Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. {ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:21129727}.
Subcellular Location Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Secreted.
Tissue Specificity Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:12907687}.
Top Pathways Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

CHSY1 CRISPR/Cas9 KO Plasmid (h) - sc-405999 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 HDR Plasmid (h) - sc-405999-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 Double Nickase Plasmid (h) - sc-405999-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 Double Nickase Plasmid (h2) - sc-405999-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 CRISPR Activation Plasmid (h) - sc-405999-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 CRISPR Activation Plasmid (h2) - sc-405999-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 Lentiviral Activation Particles (h) - sc-405999-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 Lentiviral Activation Particles (h2) - sc-405999-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHSY1 siRNA (h) - sc-60379 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHSY1 shRNA Plasmid (h) - sc-60379-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHSY1 shRNA (h) Lentiviral Particles - sc-60379-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU021001 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6118 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6118 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHSY1 siRNA (Human) - CRH7816 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHSY1 - MBS828895 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CHSY1 (NM_014918.4) - SHH263877 from Creative biogene

Category siRNA
Species Reactivities Human

Human CHSY1 siRNA - orb268318 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHSY1 shRNA Plasmid (Human) - CHH7816 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CHSY1 miRNA 3'UTR clone - MiUTR3H-09823 from Creative biogene

Species Reactivities Human
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