JAG1

Gene Symbol JAG1
Entrez Gene 182
Alt Symbol AGS, AHD, AWS, CD339, HJ1, JAGL1
Species Human
Gene Type protein-coding
Description jagged 1
Other Description protein jagged-1
Swissprots O15122 O14902 A0AV43 P78504 E9PCF9 Q15816 B4DYR1
Accessions ACH41921 ACJ68516 ACJ68517 ACJ68518 EAX10341 P78504 AF003837 AAC51731 AF028593 AAB84053 AI268246 AK302554 BAG63823 AK312722 BAG35596 BC028007 BC098393 AAH98393 BC126205 AAI26206 BC126207 AAI26208 BF056748 HQ258535 ADR83289 U61276 AAB39007 U73936 AAC52020 U77720 AAC51323 U77914 AAC50909 Z50166 NM_000214 NP_000205
Function Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:9462510}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Top Pathways Notch signaling pathway, TNF signaling pathway

Jagged1 (28H8) Rabbit mAb - 2620 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 28H8
Western blot analysis of total cell lysates from HepG2 and LNCaP cells, using Jagged1 (28H8) Rabbit mAb.

Jagged1 (1C4) Rabbit mAb - 2155 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 1C4
Western blot analysis of total cell lysates from HepG2 and LNCaP cells, using Jagged1 (1C4) Rabbit mAb.

Jagged1 (E-12) - sc-390177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Jagged1 (E-12): sc-390177. Western blot analysis of Jagged1 expression in MIA PaCa-2 (A), HeLa (B), EB1 (C) and Raji (D) whole cell lysates.

Jagged1 (C-20) - sc-6011 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Jagged expression in mouse embryo extract (A) and RAW 264.7 whole cell lysate (B). Antibodies tested include Jagged1 (C-20): sc-6011 (A) and Jagged1 (H-114): sc-8303 (B).

Jagged1 (H-66) - sc-11376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Jagged1 (H-66): sc-11376. Western blot analysis of human recombinant Jagged1 fusion protein.

Jagged1 (N-17) - sc-34473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Jagged1 (N-17): sc-34473. Western blot analysis of Jagged1 expression in mouse embryo tissue extract.

Jagged1 (T-19) - sc-34474 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Jagged1 (H-114) - sc-8303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Jagged1 (H-114): sc-8303. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing membrane staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Jagged1 (21) - sc-135955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
Jagged1 (21): sc-135955. Western blot analysis of Jagged1 expression in EB1 whole cell lysate.

Anti-Jagged1 antibody - ab7771 from Abcam

Prices $400.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-Jagged1 antibody - ab85763 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Jagged1 antibody (ab85763) at 1 µg/mlLane 1 : MEL-1 (Human embryonic stem cell, male cell line) Whole Cell Lysate (ab27198)Lane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Jagged1 antibody - ab10580 from Abcam

Host Goat
Clonality Polyclonal

Anti-Jagged1 antibody - ab124524 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Jagged1 antibody (ab124524) at 4 µg/ml + 3T3 cell lysate

Anti-Jagged1 antibody - ab54742 from Abcam

Host Mouse
Clonality Monoclonal
Anti-Jagged1 antibody (ab54742) at 5 µg/ml + 0.2 µg/lane of recombinant protein with a tagSecondaryGoat anti mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

Anti-Jagged1 antibody [EPR4290] - ab109536 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4290
Immunohistochemical staining of paraffin embedded human kidney using purified ab109536 at a dilution of 1/300. A pre-diluted HRP polymer for rabbit IgG was used as the secondary and the sample was counter stained with hematoxylin. 

Anti-Jagged1 antibody [MM0424-4A24] - ab89663 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0424-4A24

Anti-JAG1 / Jagged 1 Antibody (aa1204-1218) - LS-C8297 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-JAG1 / Jagged 1 Antibody (aa1204-1218) - LS-C3001 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-JAG1 / Jagged 1 Antibody (aa110-125) - LS-C71129 from LifeSpan Bioscience

Prices $665.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-JAG1 / Jagged 1 Antibody (aa531-621) - LS-C125832 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-JAG1 / Jagged 1 Antibody - LS-C153161 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-JAG1 / Jagged 1 Antibody (clone 12G31) - LS-C182618 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone 12G31

Anti-JAG1 / Jagged 1 Antibody (clone 12G32) - LS-C182619 from LifeSpan Bioscience

Prices $445.00
Sizes 250 µg
Host Hamster
Clonality Monoclonal
Clone 12G32

Anti-JAG1 / Jagged 1 Antibody - LS-C183442 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-JAG1 / Jagged 1 Antibody (clone HMJ1-29, PE) - LS-C106525 from LifeSpan Bioscience

Prices $275.00, $385.00
Sizes 25 µg, 100 µg
Host Hamster
Clonality Monoclonal
Clone HMJ1-29
Flo Staining of CD8+CD11c+ C57Bl/6 splenocytes with 0.5 ug of PE Armenian Hamster IgG isotype control (blue histogram) or 0.5 ug of PE anti-mouse Jagged-1 (purple histogram). Total viable cells were used for analysis.
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