| Gene Symbol |
Hcst
|
| Entrez Gene |
23900
|
| Alt Symbol |
DAP10, KAP10
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
hematopoietic cell signal transducer
|
| Other Description |
DNAX-activation protein 10|membrane protein DAP10|transmembrane adapter protein KAP10
|
| Swissprots |
Q9R1E7 Q9QUJ0
|
| Accessions |
AAK52752 EDL24024 EDL24025 Q9QUJ0 AF072846 AAD46988 AF122905 AAD47912 AF172930 AAD50294 AK008005 BAB25404 BC069220 AAH69220 BC145545 AAI45546 BC145824 AAI45825 BC145826 AAI45827 NM_011827 NP_035957
|
| Function |
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST rece
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:17100879}; Single-pass type I membrane protein {ECO:0000269|PubMed:17100879}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|