Hcst

Gene Symbol Hcst
Entrez Gene 23900
Alt Symbol DAP10, KAP10
Species Mouse
Gene Type protein-coding
Description hematopoietic cell signal transducer
Other Description DNAX-activation protein 10|membrane protein DAP10|transmembrane adapter protein KAP10
Swissprots Q9R1E7 Q9QUJ0
Accessions AAK52752 EDL24024 EDL24025 Q9QUJ0 AF072846 AAD46988 AF122905 AAD47912 AF172930 AAD50294 AK008005 BAB25404 BC069220 AAH69220 BC145545 AAI45546 BC145824 AAI45825 BC145826 AAI45827 NM_011827 NP_035957
Function Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST rece
Subcellular Location Membrane {ECO:0000269|PubMed:17100879}; Single-pass type I membrane protein {ECO:0000269|PubMed:17100879}.
Top Pathways Natural killer cell mediated cytotoxicity

DAP10 CRISPR/Cas9 KO Plasmid (m) - sc-423889 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 HDR Plasmid (m) - sc-423889-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 Double Nickase Plasmid (m) - sc-423889-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 Double Nickase Plasmid (m2) - sc-423889-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 CRISPR Activation Plasmid (m) - sc-423889-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 CRISPR Activation Plasmid (m2) - sc-423889-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 Lentiviral Activation Particles (m) - sc-423889-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 Lentiviral Activation Particles (m2) - sc-423889-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DAP10 siRNA (m) - sc-42853 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

DAP10 shRNA Plasmid (m) - sc-42853-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

DAP10 shRNA (m) Lentiviral Particles - sc-42853-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN33130 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33130 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HCST siRNA (Mouse) - CRM4573 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

HCST - MBS8225602 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Hc (NM_011827.3) - SHH310709 from Creative biogene

Category siRNA
Species Reactivities Mouse

HCST shRNA Plasmid (Mouse) - CHM4573 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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