TNF

Gene Symbol TNF
Entrez Gene 7124
Alt Symbol DIF, TNF-alpha, TNFA, TNFSF2
Species Human
Gene Type protein-coding
Description tumor necrosis factor
Other Description APC1 protein|TNF, macrophage-derived|TNF, monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha
Swissprots Q9P1Q2 Q9UIV3 P01375 O43647
Accessions AAA36758 AAA61200 AAB01765 AAD18091 AAL47581 AAO21132 AAV63951 AHJ25918 AHJ25919 AHJ25920 AHJ25921 AHJ25922 AHJ25923 AHJ25924 AHJ25925 BAB63396 BAC54944 BAE78639 BAF31279 CAA26669 CAA75070 CAA78745 CAB65595 CAI95946 EAX03424 P01375 AB451492 BAG70306 AF043342 AAC03542 AF098751 AAF71992 AJ227911 AJ251878 CAB63904 AJ251879 CAB63905 AK314960 BAG37464 BC028148 AAH28148 BI908079 BP215875 CA306559 DQ891662 ABM82588 DQ894849 ABM85775 FJ795028 ACO37640 HQ201306 ADV31546 M10988 AAA61198 M35592 AAC42098 X01394 CAA25650 NM_000594 NP_000585
Function Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:23396208}.
Subcellular Location C-domain 2: Secreted.
Top Pathways TNF signaling pathway, Proteoglycans in cancer, Sphingolipid signaling pathway, NOD-like receptor signaling pathway, Rheumatoid arthritis

TNF-Over-expression-Lysate - LY10460a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag TNF (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TNF gene (Lane 2, Cat. #LY10460a).

TNF 293 Cell Lysate - 410186 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Disease Tumor

TNF-alpha Overexpression Lysate (Native) - NBL1-17134 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TNF alpha Overexpression Lysate (Adult Normal) [NBL1-17134] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TNF alpha.

TNF Over-expression Lysate Product - GWB-448BBB from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Human TNF-alpha / TNFA HEK293 Cell Lysate (WB positive control) - 10602-H01HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Panoply™ Human TNF Knockdown Stable Cell Line - CSC-DC016340 from Creative biogene

Category Cell Line
Species Human
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