TNF

Gene Symbol TNF
Entrez Gene 7124
Alt Symbol DIF, TNF-alpha, TNFA, TNFSF2
Species Human
Gene Type protein-coding
Description tumor necrosis factor
Other Description APC1 protein|TNF, macrophage-derived|TNF, monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha
Swissprots Q9P1Q2 Q9UIV3 P01375 O43647
Accessions AAA36758 AAA61200 AAB01765 AAD18091 AAL47581 AAO21132 AAV63951 AHJ25918 AHJ25919 AHJ25920 AHJ25921 AHJ25922 AHJ25923 AHJ25924 AHJ25925 BAB63396 BAC54944 BAE78639 BAF31279 CAA26669 CAA75070 CAA78745 CAB65595 CAI95946 EAX03424 P01375 AB451492 BAG70306 AF043342 AAC03542 AF098751 AAF71992 AJ227911 AJ251878 CAB63904 AJ251879 CAB63905 AK314960 BAG37464 BC028148 AAH28148 BI908079 BP215875 CA306559 DQ891662 ABM82588 DQ894849 ABM85775 FJ795028 ACO37640 HQ201306 ADV31546 M10988 AAA61198 M35592 AAC42098 X01394 CAA25650 NM_000594 NP_000585
Function Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:23396208}.
Subcellular Location C-domain 2: Secreted.
Top Pathways TNF signaling pathway, Proteoglycans in cancer, Sphingolipid signaling pathway, NOD-like receptor signaling pathway, Rheumatoid arthritis

TNFα CRISPR/Cas9 KO Plasmid (h) - sc-400124 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα HDR Plasmid (h) - sc-400124-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα Double Nickase Plasmid (h) - sc-400124-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα Double Nickase Plasmid (h2) - sc-400124-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα CRISPR Activation Plasmid (h) - sc-400124-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα CRISPR Activation Plasmid (h2) - sc-400124-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα Lentiviral Activation Particles (h) - sc-400124-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα Lentiviral Activation Particles (h2) - sc-400124-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNFα siRNA (h) - sc-37216 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TNFα shRNA Plasmid (h) - sc-37216-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TNFα shRNA (h) Lentiviral Particles - sc-37216-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TNF-alpha RNAi - H00007124-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1756 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1756 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00017 from Sigma-Aldrich

Category miRNA
Prices $522.00
Sizes hutr00017

TNF siRNA (Human) - CRH4885 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNF - MBS8211454 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TNF (NM_000594.3) - SHH431736 from Creative biogene

Category siRNA
Species Reactivities Human

TNF shRNA Plasmid (Human) - CHH4885 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TNF miRNA 3'UTR clone - MiUTR3H-02321 from Creative biogene

Species Reactivities Human
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