| Gene Symbol |
Sumo1
|
| Entrez Gene |
22218
|
| Alt Symbol |
GMP1, PIC1, SENTRIN, SMT3, SMT3H3, SMTP3, SUMO-1, Smt3C, Ubl1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
SMT3 suppressor of mif two 3 homolog 1 (yeast)
|
| Other Description |
SMT3 homolog 3|SUMO-1 related peptidase|small ubiquitin-related modifier 1|ubiquitin-homology domain protein PIC1|ubiquitin-like 1|ubiquitin-like protein SMT3C
|
| Swissprots |
P63166 Q3TX92
|
| Accessions |
EDL00133 P63166 AF033353 AAC39959 AK002536 BAB22172 AK011074 BAB27379 AK012235 AK089081 BAC40739 AK159366 BAE35024 AK220052 BC082566 AAH82566 BC083158 AAH83158 BE691755 BY242724 NM_009460 NP_033486
|
| Function |
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. {ECO:0000269|PubMed:16990542}.
|
| Subcellular Location |
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body {ECO:0000250}. Note=Recruited by BCL11A into the nuclear body.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
RNA transport
|
![ab196310 staining Sumo 1 in NIH3T3 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilised in 0.1% Triton X-100 for 5 minutes and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated with ab196310 at 1/50 dilution (shown in green) and ab195889, Mouse monoclonal [DM1A] to alpha Tubulin (Alexa Fluor® 594, shown in red) at 1/167 dilution overnight at +4°C. Nuclear DNA was labelled in blue with DAPI.This product gave a positive signal in 100% methanol (5 min) fixed NIH3T3 cells under the same testing conditions.Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_5/6767_ab196310-237618-AP218756301.jpg)
![ab196533 staining Sumo 1 in NIH3T3 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilised in 0.1% Triton X-100 for 5 minutes and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated with ab196533 at 1/50 dilution (shown in red) and ab195887, Mouse monoclonal [DM1A] to alpha Tubulin (Alexa Fluor® 594, shown in green) at 1/167 dilution overnight at +4°C. Nuclear DNA was labelled in blue with DAPI.This product gave a positive signal in 100% methanol (5 min) fixed NIH3T3 cells under the same testing conditions.Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_5/6768_ab196533-237622-ICCAP219899102.jpg)
