| Gene Symbol | PILRA |
|---|---|
| Entrez Gene | 29992 |
| Alt Symbol | FDF03 |
| Species | Human |
| Gene Type | protein-coding |
| Description | paired immunoglobin-like type 2 receptor alpha |
| Other Description | cell surface receptor FDF03|inhibitory receptor PILR-alpha|paired immunoglobulin-like type 2 receptor alpha |
| Swissprots | Q9UKJ1 Q8NHI1 |
| Accessions | EAL23835 EAL23836 EAL23837 EAW76542 EAW76543 EAW76544 EAW76545 Q9UKJ1 AF161080 AAD52964 AJ400841 CAC01613 AJ400842 CAC01614 AJ400843 CAC01615 AK298731 BAG60881 BC017812 AAH17812 BF432841 NM_013439 NP_038467 NM_178272 NP_840056 NM_178273 NP_840057 |
| Function | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:18358807, ECO:0000269|PubMed:21241660}. |
| Subcellular Location | Isoform 3: Secreted {ECO:0000305}. |
| Tissue Specificity | Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. {ECO:0000269|PubMed:10903717}. |
| Top Pathways | Herpes simplex infection |