PILRA

Gene Symbol	PILRA
Entrez Gene	29992
Alt Symbol	FDF03
Species	Human
Gene Type	protein-coding
Description	paired immunoglobin-like type 2 receptor alpha
Other Description	cell surface receptor FDF03|inhibitory receptor PILR-alpha|paired immunoglobulin-like type 2 receptor alpha
Swissprots	Q9UKJ1 Q8NHI1
Accessions	EAL23835 EAL23836 EAL23837 EAW76542 EAW76543 EAW76544 EAW76545 Q9UKJ1 AF161080 AAD52964 AJ400841 CAC01613 AJ400842 CAC01614 AJ400843 CAC01615 AK298731 BAG60881 BC017812 AAH17812 BF432841 NM_013439 NP_038467 NM_178272 NP_840056 NM_178273 NP_840057
Function	Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:18358807, ECO:0000269|PubMed:21241660}.
Subcellular Location	Isoform 3: Secreted {ECO:0000305}.
Tissue Specificity	Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. {ECO:0000269|PubMed:10903717}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PILRA full length protein - ab162304 from Abcam Category Protein Source Wheat germ Species Human

PILR-alpha Recombinant Protein - H00029992-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PILR-alpha, CF - 6484-PR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln20-Thr196 with a C-terminal 6-His tag

PILRA protein - orb171535 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

PILRA protein - orb171534 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

PILRA Blocking Peptide - 33R-4090 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PILRA - H00029992-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PILRA - H00029992-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PILRA fusion protein - ag2385 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PILRA - PILRA-362H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human PILRA, Fc-tagged - PILRA-363H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human PILRA, His-tagged - PILRA-513H from Creative Biomart Category Protein Source NSO cells Species Human

Human PILR-alpha / PILRA Protein (Fc Tag) - 13791-H02H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human PILR-alpha / PILRA Protein - 13791-HCCH-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human PILR-alpha / PILRA Protein (His Tag) - 13791-H08H-100 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Recombinant Human Paired immunoglobulin-like type 2 receptor alpha(PILRA) - CSB-YP892331HU CSB-EP892331HU CSB-BP892331HU CSB-MP892331HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human PILR-alpha Protein, CF - 6484-PR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Gln20-Thr196 with a C-terminal 6-His tag Species Human

Paired immunoglobulin-like type 2 receptor alpha (PILRA), Recombinant Protein - MBS1296175 from MyBioSource Category Protein Prices $925.00, $925.00, $1,145.00, $1,145.00, $1,375.00, $1,375.00, $1,830.00, $1,830.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human PILRA Protein, His-tagged - PILRA-578H from Creative Biomart Category Protein Source HEK293 Species Human

PILR-alpha Protein - NBP2-13763PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

PILRA Peptide, Human - M34GP11795H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human PILR-alpha / PILRA Protein (Fc Tag) - 13791-H02H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human PILR-alpha / PILRA Protein (His Tag) - 13791-H08H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human PILR-alpha / PILRA Protein - 13791-HCCH from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

PILR-alpha Recombinant Protein Antigen - NBP2-55310PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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