RPSA

Gene Symbol	RPSA
Entrez Gene	3921
Alt Symbol	37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40
Species	Human
Gene Type	protein-coding
Description	ribosomal protein SA
Other Description	37 kDa laminin receptor|37/67 kDa laminin receptor|40S ribosomal protein SA|67 kDa laminin receptor|colon carcinoma laminin-binding protein|laminin receptor 1 (67kD, ribosomal protein SA)|laminin-binding protein precursor p40|multidrug resistance-associated protein MGr1-Ag
Swissprots	P11085 Q6IPD1 P12030 Q86VC0 Q6IPD2 Q16471 Q6NXQ8 Q6NSD1 P08865
Accessions	AAC50313 AAC50652 BAA25812 EAW64582 EAW64583 EAW64584 EAW64585 EAW64586 EAW64587 P08865 AF503367 AAM33304 AJ572067 AK055991 BC005391 AAH05391 BC008867 AAH08867 BC010418 AAH10418 BC013827 AAH13827 BC018867 BC034537 AAH34537 BC050688 AAH50688 BC053370 AAH53370 BC062714 AAH62714 BC066941 AAH66941 BC068062 AAH68062 BC070263 AAH70263 BC071693 AAH71693 BC071968 AAH71968 BC071969 AAH71969 BC071970 AAH71970 BC073863 AAH73863 BC107567 AAI07568 BM999786 BT007219 AAP35883 BU932677 D28372 BAA05738 DQ891146 ABM82072 DQ894326 ABM85252 J03799 AAA36161 M14199 AAA36165 S37431 AAB22299 X15005 CAA33112 X61156 CAA43469 NM_001304288 NP_001291217 NM_002295 NP_002286
Function	Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:15516338, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.
Subcellular Location	Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP-Rule:MF_03016}.
Top Pathways	Ribosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RPSA-Over-expression-Lysate - LY12856a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

RPSA 293 Cell Lysate - 400791 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RPSA Overexpression Lysate (Native) - NBL1-15579 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RPSA Overexpression Lysate (Native) - NBL1-15578 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Laminin-R (h2): 293T Lysate - sc-116343 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Laminin-R (h4): 293T Lysate - sc-117344 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Laminin-R (h6): 293T Lysate - sc-159313 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RPSA Over-expression Lysate Product - GWB-5A45C3 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human RPSA Knockdown Stable Cell Line - CSC-DC013608 from Creative biogene Category Cell Line Species Human

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