RPSA

Gene Symbol RPSA
Entrez Gene 3921
Alt Symbol 37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40
Species Human
Gene Type protein-coding
Description ribosomal protein SA
Other Description 37 kDa laminin receptor|37/67 kDa laminin receptor|40S ribosomal protein SA|67 kDa laminin receptor|colon carcinoma laminin-binding protein|laminin receptor 1 (67kD, ribosomal protein SA)|laminin-binding protein precursor p40|multidrug resistance-associated protein MGr1-Ag
Swissprots P11085 Q6IPD1 P12030 Q86VC0 Q6IPD2 Q16471 Q6NXQ8 Q6NSD1 P08865
Accessions AAC50313 AAC50652 BAA25812 EAW64582 EAW64583 EAW64584 EAW64585 EAW64586 EAW64587 P08865 AF503367 AAM33304 AJ572067 AK055991 BC005391 AAH05391 BC008867 AAH08867 BC010418 AAH10418 BC013827 AAH13827 BC018867 BC034537 AAH34537 BC050688 AAH50688 BC053370 AAH53370 BC062714 AAH62714 BC066941 AAH66941 BC068062 AAH68062 BC070263 AAH70263 BC071693 AAH71693 BC071968 AAH71968 BC071969 AAH71969 BC071970 AAH71970 BC073863 AAH73863 BC107567 AAI07568 BM999786 BT007219 AAP35883 BU932677 D28372 BAA05738 DQ891146 ABM82072 DQ894326 ABM85252 J03799 AAA36161 M14199 AAA36165 S37431 AAB22299 X15005 CAA33112 X61156 CAA43469 NM_001304288 NP_001291217 NM_002295 NP_002286
Function Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:15516338, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.
Subcellular Location Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP-Rule:MF_03016}.
Top Pathways Ribosome

Laminin-R CRISPR/Cas9 KO Plasmid (h) - sc-417155 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R HDR Plasmid (h) - sc-417155-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R Double Nickase Plasmid (h) - sc-417155-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R Double Nickase Plasmid (h2) - sc-417155-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R CRISPR Activation Plasmid (h) - sc-417155-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R CRISPR Activation Plasmid (h2) - sc-417155-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R Lentiviral Activation Particles (h) - sc-417155-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R Lentiviral Activation Particles (h2) - sc-417155-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Laminin-R siRNA (h) - sc-35789 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Laminin-R shRNA Plasmid (h) - sc-35789-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Laminin-R shRNA (h) Lentiviral Particles - sc-35789-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RPSA RNAi - H00003921-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

RPSA RNAi - H00003921-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU109791 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU118071 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18664 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18664 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00282 from Sigma-Aldrich

Category miRNA

RPSA siRNA (Human) - CRH2658 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RPSA - MBS8235605 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RPSA(NM_001012321.1) - SHR198222 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RPSA(NM_002295.4) - SHR198318 from Creative biogene

Category siRNA
Species Reactivities Human

RPSA shRNA Plasmid (Human) - CHH2658 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RPSA miRNA 3'UTR clone - MiUTR1H-09036 from Creative biogene

Species Reactivities Human

RPSA miRNA 3'UTR clone - MiUTR1H-09037 from Creative biogene

Species Reactivities Human
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