LIMK2
| Gene Symbol | LIMK2 |
|---|---|
| Entrez Gene | 3985 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | LIM domain kinase 2 |
| Other Description | - |
| Swissprots | Q9UFU0 Q96E10 Q7L3H5 Q7KZ80 P53671 A8K6H5 Q99464 |
| Accessions | AAB54055 AAB54056 BAA36742 CCQ43329 CCQ43330 EAW59954 EAW59955 EAW59956 EAW59957 EAW59958 EAW59959 P53671 AB451269 BAG70083 AB451396 BAG70210 AK092838 AK093554 BAG52739 AK291640 BAF84329 AK293774 BAG57190 AK299112 BAG61168 AK302553 BAG63822 AK314391 BAG37016 AL117466 CAB55941 AM393090 CAL37968 BC013051 AAH13051 BU553494 BX385507 CR456513 CAG30399 CU013112 CAK54543 CU013400 CAK54842 D45906 BAA08312 D85527 BAA12827 NM_001031801 NP_001026971 NM_005569 NP_005560 NM_016733 NP_057952 |
| Function | Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042}. |
| Subcellular Location | Isoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus. |
| Tissue Specificity | Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. {ECO:0000269|PubMed:8954941}. |
| Top Pathways | Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton |
LIMK-2 CRISPR/Cas9 KO Plasmid (h) - sc-401296 from Santa Cruz Biotechnology
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LIMK-2 HDR Plasmid (h) - sc-401296-HDR from Santa Cruz Biotechnology
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LIMK-2 Double Nickase Plasmid (h) - sc-401296-NIC from Santa Cruz Biotechnology
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LIMK-2 Double Nickase Plasmid (h2) - sc-401296-NIC-2 from Santa Cruz Biotechnology
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LIMK-2 CRISPR Activation Plasmid (h) - sc-401296-ACT from Santa Cruz Biotechnology
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LIMK-2 CRISPR Activation Plasmid (h2) - sc-401296-ACT-2 from Santa Cruz Biotechnology
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LIMK-2 Lentiviral Activation Particles (h) - sc-401296-LAC from Santa Cruz Biotechnology
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LIMK-2 Lentiviral Activation Particles (h2) - sc-401296-LAC-2 from Santa Cruz Biotechnology
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LIMK-2 siRNA (h) - sc-35812 from Santa Cruz Biotechnology
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LIMK-2 shRNA Plasmid (h) - sc-35812-SH from Santa Cruz Biotechnology
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LIMK-2 shRNA (h) Lentiviral Particles - sc-35812-V from Santa Cruz Biotechnology
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LIM kinase 2 RNAi - H00003985-R01 from Novus Biologicals
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MISSION® esiRNA - EHU147391 from Sigma-Aldrich
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MISSION® siRNA - SIHK1054 from Sigma-Aldrich
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MISSION® siRNA - SIHK1055 from Sigma-Aldrich
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MISSION® siRNA - SIHK1053 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11724 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11724 from Sigma-Aldrich
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LIMK2 siRNA (Human) - CRH2698 from Cohesion Biosciences
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LIM kinase 2 RNAi - H00003985-R07 from Novus Biologicals
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LIM kinase 2 RNAi - H00003985-R06 from Novus Biologicals
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shRNA set against Human LIMK2 (NM_005569.3) - SHH330419 from Creative biogene
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shRNA set against Human LIMK2(NM_005569.3) - SHH150095 from Creative biogene
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shRNA set against Human LIMK2(NM_001031801.1) - SHH150167 from Creative biogene
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shRNA set against Human LIMK2(NM_016733.2) - SHH150185 from Creative biogene
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