DUT

Gene Symbol DUT
Entrez Gene 1854
Alt Symbol dUTPase
Species Human
Gene Type protein-coding
Description deoxyuridine triphosphatase
Other Description dUTP diphosphatase|dUTP nucleotidohydrolase|dUTP pyrophosphatase|deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Swissprots Q6NSA3 Q16860 Q16708 Q6FHN1 A8K650 P33316 B4DPR5 O14785 Q96Q81
Accessions AAB71393 AAB71394 AAB93866 AAB93867 AAX14045 EAW77349 EAW77350 EAW77351 EAW77352 P33316 AB049113 BAB13724 AK000629 AK291515 BAF84204 AK298464 BAG60677 AK312122 BAG35058 BC033645 AAH33645 BC070339 AAH70339 BC110377 AAI10378 BF697257 BG505144 BG532018 BI257870 CR541720 CAG46521 CR541781 CAG46580 DQ891191 ABM82117 DQ894375 ABM85301 L11877 AAA36801 M89913 AAA58444 U31930 AAC50418 U62891 AAC51123 U90223 AAB94642 XM_011521315 XP_011519617 XR_931760 NM_001025248 NP_001020419 NM_001025249 NP_001020420 NM_001948 NP_001939
Function This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. {ECO:0000269|PubMed:8805593}.
Subcellular Location Isoform 2: Nucleus.
Tissue Specificity Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). {ECO:0000269|PubMed:9228092}.
Top Pathways Pyrimidine metabolism

dUTPase (H-9) - sc-166856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
dUTPase (H-9): sc-166856. Western blot analysis of dUTPase expression in Jurkat whole cell lysate.

dUTPase (F-17) - sc-68073 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
dUTPase (F-17): sc-68073. Western blot analysis of dUTPase expression in non-transfected 293T: sc-117752 (A), human dUTPase transfected 293T: sc-115300 (B) and Ramos (C) whole cell lysates.

dUTPase (G-6) - sc-166838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
dUTPase (G-6): sc-166838. Western blot analysis of dUTPase expression in non-transfected 293T: sc-117752 (A), human dUTPase transfected 293T: sc-115300 (B) and HeLa (C) whole cell lysates.

dUTPase (A-13) - sc-68069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
dUTPase (A-13): sc-68069. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

dUTPase (D-16) - sc-68071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

dUTPase (F-6) - sc-166758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
dUTPase (F-6): sc-166758. Western blot analysis of dUTPase expression in HeLa whole cell lysate.

Anti-DUT antibody - ab65971 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab65971 at 1µg/ml staining DUT-N in the cytoplasm of paraffin-embedded rat tissue sections (cardiac muscle). (DAB chromogenic reaction)

Anti-DUT antibody - ab54942 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
DUT-N antibody (ab54942) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human colon.

Anti-DUT antibody - ab65444 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DUT antibody (ab65444) at 2.5 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DUT antibody - ab123135 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DUT antibody (ab123135) at 1/100 dilution + Human normal uterus cell line lysates at 35 µg

Anti-DUT antibody - ab171886 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DUT antibody (ab171886) at 1 µg/mlLane 1 : DUT transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-DUT antibody - ab13690 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DUT antibody [EPR9607(B)] - ab137102 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9607(B)
All lanes : Anti-DUT antibody [EPR9607(B)] (ab137102) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : Jurkat cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-DUT antibody [EPR9608(B)] - ab137097 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9608(B)
All lanes : Anti-DUT antibody [EPR9608(B)] (ab137097) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : Ramos cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-labelled Goat anti-Rabbit at 1/2000 dilution

Anti-DUT / DUTPase Antibody (aa136-150) - LS-C312268 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
DUT / DUTPase antibody. IHC(P): Human Intestinal Cancer Tissue.

Anti-DUT / DUTPase Antibody (clone 1C9) IHC-plus™ - LS-B4315 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C9
Anti-DUT antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4315 concentration 5 ug/ml.

Anti-DUT / DUTPase Antibody - LS-C121723 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DUT / DUTPase Antibody (aa136-150) - LS-C121724 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DUT / DUTPase Antibody (Internal, Magnetic beads) - LS-C171556 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DUT / DUTPase Antibody (C-Terminus) - LS-C80791 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
DUT antibody LS-C80791 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

Anti-DUT / DUTPase Antibody (Internal, Sepharose) - LS-C171557 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DUT / DUTPase Antibody (aa35-84) - LS-C111078 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry with Jurkat cell lysate tissue.

Anti-DUT / DUTPase Antibody (aa25-44) - LS-C190727 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUT / DUTPase Antibody (aa170-198, APC) - LS-C222299 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUT / DUTPase Antibody (aa170-198, AP) - LS-C222298 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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