| Gene Symbol |
KCNJ5
|
| Entrez Gene |
3762
|
| Alt Symbol |
CIR, GIRK4, KATP1, KIR3.4, LQT13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 5
|
| Other Description |
G protein-activated inward rectifier potassium channel 4|IRK-4|cardiac ATP-sensitive potassium channel|heart KATP channel|inward rectifier K+ channel KIR3.4|potassium inwardly-rectifying channel, subfamily J, member 5
|
| Swissprots |
Q6DK13 B2R744 Q6DK14 P48544 Q92807
|
| Accessions |
EAW67726 EAW67727 P48544 AB690268 BAL72885 AK312837 BAG35691 BC069386 AAH69386 BC069482 AAH69482 BC069499 AAH69499 BC069571 AAH69571 BC074838 AAH74838 BC074839 AAH74839 BC096834 AAH96834 BX647543 D50134 BAA08814 HQ447428 ADQ31914 JN859132 AFB82769 JN859133 AFB82770 L47208 AAB07269 U39195 AAB53093 X83582 CAA58565 XM_011542809 XP_011541111 XM_011542810 XP_011541112 NM_000890 NP_000881
|
| Function |
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa. {ECO:0000269|PubMed:21311022}.
|
| Top Pathways |
Dopaminergic synapse, Morphine addiction, Retrograde endocannabinoid signaling, Circadian entrainment, Estrogen signaling pathway
|