FBP1

Gene Symbol	FBP1
Entrez Gene	2203
Alt Symbol	FBP
Species	Human
Gene Type	protein-coding
Description	fructose-1,6-bisphosphatase 1
Other Description	D-fructose-1,6-bisphosphate 1-phosphohydrolase 1|FBPase 1|fructose-bisphosphatase 1|growth-inhibiting protein 17|liver FBPase
Swissprots	P09467 Q53F94 Q96E46 O75571
Accessions	AAC50207 AAW34363 BAF91908 CBF86692 CBG16870 CBV02277 CBV30316 EAW92617 P09467 AF073475 AAC25774 AK223395 BAD97115 AK292199 BAF84888 AK316583 BAG38171 AY544122 AAT11153 BC012927 AAH12927 D26054 BAA05051 D26055 BAA05052 D26056 BAA05053 DA962803 L10320 AAA35817 M19922 AAA35517 U47918 AAA89097 U47919 AAA89098 XM_006717005 XP_006717068 NM_000507 NP_000498 NM_001127628 NP_001121100
Function	Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.
Tissue Specificity	Expressed in pancreatic islets. {ECO:0000269|PubMed:18375435}.
Top Pathways	Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBP1 full length protein - ab185407 from Abcam Category Protein Source Mammalian Species Human

Human FBP1 full length protein - ab89244 from Abcam Category Protein Source E. coli Species Human

FBP / FOLR2 Antibody Blocking Peptide - LS-E3836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBP / FOLR2 Antibody Blocking Peptide - LS-E7702 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBP / FOLR2 Antibody Blocking Peptide - LS-E23976 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBP1 Antibody Blocking Peptide - LS-E8912 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBP1 Antibody Blocking Peptide - LS-E8913 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBP1 Antibody Blocking Peptide - LS-E15233 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBPase 1 Recombinant Protein - H00002203-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human FBPase 1 Protein - NBP1-30268 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

FBP1-Antibody-Center-Blocking-Peptide - BP7385c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBP1-Antibody-N-term-Blocking-Peptide - BP7385a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBP1 Protein (OPPA02145) - OPPA02145 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Fructose-1,6-Bisphosphatase 1 protein - orb90091 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

Human FBPase 1 protein - orb49393 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human FBPase 1 protein - orb180273 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

FBP1 Blocking Peptide - 33R-10289 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBP1 protein (His tag) - 80R-1207 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

FBP1 (1-338, His-tag) - AR09291PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

FBP1 (1-338, His-tag) - AR09291PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

FBP1 - H00002203-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBP1 - H00002203-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Fructose-1,6-Bisphosphatase 1, Human Recombinant - 228-12475-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Fructose-1,6-Bisphosphatase 1 Human - 228-12475-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Fructose-1,6-Bisphosphatase 1 Human - 228-12475-3 from RayBiotech Category Protein Prices $2,400.00 Sizes 3 µg Source Escherichia Coli. Species Human

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