FBP1

Gene Symbol FBP1
Entrez Gene 2203
Alt Symbol FBP
Species Human
Gene Type protein-coding
Description fructose-1,6-bisphosphatase 1
Other Description D-fructose-1,6-bisphosphate 1-phosphohydrolase 1|FBPase 1|fructose-bisphosphatase 1|growth-inhibiting protein 17|liver FBPase
Swissprots P09467 Q53F94 Q96E46 O75571
Accessions AAC50207 AAW34363 BAF91908 CBF86692 CBG16870 CBV02277 CBV30316 EAW92617 P09467 AF073475 AAC25774 AK223395 BAD97115 AK292199 BAF84888 AK316583 BAG38171 AY544122 AAT11153 BC012927 AAH12927 D26054 BAA05051 D26055 BAA05052 D26056 BAA05053 DA962803 L10320 AAA35817 M19922 AAA35517 U47918 AAA89097 U47919 AAA89098 XM_006717005 XP_006717068 NM_000507 NP_000498 NM_001127628 NP_001121100
Function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.
Tissue Specificity Expressed in pancreatic islets. {ECO:0000269|PubMed:18375435}.
Top Pathways Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

FBPase CRISPR/Cas9 KO Plasmid (h) - sc-404693 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBPase HDR Plasmid (h) - sc-404693-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBPase Double Nickase Plasmid (h) - sc-404693-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBPase Double Nickase Plasmid (h2) - sc-404693-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBPase CRISPR Activation Plasmid (h) - sc-404693-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBPase CRISPR Activation Plasmid (h2) - sc-404693-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBPase Lentiviral Activation Particles (h) - sc-404693-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBPase Lentiviral Activation Particles (h2) - sc-404693-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

liver FBPase siRNA (h) - sc-45235 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

liver FBPase shRNA Plasmid (h) - sc-45235-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

liver FBPase shRNA (h) Lentiviral Particles - sc-45235-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU032021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0222 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0220 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0959 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0221 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN1917 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1917 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FBP1 siRNA (Human) - CRH1538 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBPase 1 RNAi - H00002203-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

FBP1 - MBS8210948 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBP1(NM_000507.3) - SHH050591 from Creative biogene

Category siRNA
Species Reactivities Human

Human FBP1 siRNA - orb262040 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBP1 shRNA Plasmid (Human) - CHH1538 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBP1 miRNA 3'UTR clone - MiUTR1H-03536 from Creative biogene

Species Reactivities Human
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