ISG15

Gene Symbol	ISG15
Entrez Gene	9636
Alt Symbol	G1P2, IFI15, IMD38, IP17, UCRP, hUCRP
Species	Human
Gene Type	protein-coding
Description	ISG15 ubiquitin-like modifier
Other Description	interferon, alpha-inducible protein (clone IFI-15K)|interferon-induced 17-kDa/15-kDa protein|interferon-stimulated protein, 15 kDa|ubiquitin cross-reactive protein|ubiquitin-like protein ISG15
Swissprots	Q7Z2G2 P05161 Q96GF0 Q5SVA4
Accessions	AAA36128 EAW56295 P05161 AY168648 AAN86983 BC009507 AAH09507 BM712238 BT007297 AAP35961 BU161226 DQ892714 ABM83640 EU176738 ABW03539 M13755 AAA36038 NM_005101 NP_005092
Function	Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation- inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA- induced JNK signaling. Exhibits antiviral activity towards
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:22859821}. Secreted {ECO:0000269|PubMed:22859821}. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins.
Tissue Specificity	Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. Expressed in neutrophils, monocytes and lymphocytes. Enhanced expression seen in pancreatic adenocarcinoma, endometrial cancer, and bladder cancer, as compared to non-cancerous tissue. In bladder cancer, the increase in expression exhibits a striking positive correlation with more advanced stages of the disease. {ECO:0000269|PubMed:22859821, ECO:0000269|PubMed:7490683}.
Top Pathways	RIG-I-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ISG15 ELISA Kit (Sandwich ELISA) - LS-F7970 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 31.25 pg/ml Range 31.25-2000 pg/ml

Human ISG15 ELISA Kit (Sandwich ELISA) - LS-F11841 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 31.25-2000 pg/ml

ISG15 Conjugation Kit - K-600 from R&D Systems Prices $335.00 Sizes 1 kit

Ubiquitin Cross Reactive Protein (UCRP), Human, ELISA Kit - SEL630Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 12.5pg/mL Range 31.2-2,000pg/mL

Ubiquitin-like modifier (ISG15), Human, ELISA Kit - CSB-E12075h from ARP American Research Products Category ELISA Kit Prices $565.00, $835.00, $837.00, $839.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.195 ng/ml Range 0.78 ng/ml-50 ng/ml

Ubiquitin-like protein ISG15, ISG15, Human, ELISA Kit - E14926h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 31.2-2000 pg/mL

Interferon Stimulated Gene 15, ISG15, Human, ELISA Kit - E-EL-H0203 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Ubiquitin Cross Reactive Protein, UCRP, Human, ELISA Kit - E-EL-H2531 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Ubiquitin Cross Reactive Protein, UCRP, Rabbit, ELISA Kit - E-EL-RB0215 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Cross Reactive Protein, UCRP, Chicken, ELISA Kit - E-EL-Ch0928 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Ubiquitin Cross Reactive Protein, UCRP, Porcine, ELISA Kit - E-EL-P0188 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Cross Reactive Protein, UCRP, Monkey, ELISA Kit - E-EL-MK2074 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Cross Reactive Protein (UCRP), Human, CLIA Kit - SCL630Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.105ng/mL Range 0.312-20ng/mL

ISG15 (Human) ELISA Kit - DEIA3822 from Creative Diagnostics Category ELISA Kit Sensitivity The limit of detection (defined as such a concentration of human ISG15 giving absorbance higher than mean absorbance of blank plus three standard deviations of the absorbance of blank: A blank + 3SD blank) is better than 0.85 ng/mL of sample. Range Results exceeding human ISG15 level of the highest ISG15 Standard should be repeated with diluted samples. Dilution factors need to be taken into consideration in calculating the human ISG15 concentration.

Human ISG15(Interferon Stimulated Gene 15) ELISA Kit - E-EL-H0203 from Elabscience Category ELISA Kit Sensitivity 18.75 pg/mL Range 31.25—2000 pg/mL

Human UCRP(Ubiquitin Cross Reactive Protein) ELISA Kit - E-EL-H2531 from Elabscience Category ELISA Kit Sensitivity 18.75 pg/mL Range 31.25—2000 pg/mL

Human ISG15 (Interferon Stimulated Gene 15) CLIA Kit - E-CL-H0185 from Elabscience Category CLIA Kit Sensitivity 18.75pg/mL Range 31.25~2000pg/mL

Human UCRP (Ubiquitin Cross Reactive Protein) CLIA Kit - E-CL-H1444 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

Ischemia Modified Albumin, IMA, ELISA Kit - MBS705008 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.78 IU/ml Range 3.12 IU/ml-200 IU/ml

ISG15 ubiquitin-like modifier, ELISA Kit - MBS700182 from MyBioSource Category ELISA Kit Prices $250.00, $575.00, $835.00, $3,040.00, $5,755.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ISG15 is typically less than 0.195 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.78 ng/ml-50 ng/ml.

Ubiquitin Cross Reactive Protein, ELISA Kit - MBS101633 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Cross Reactive Protein, ELISA Kit - MBS065028 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Cross Reactive Protein, ELISA Kit - MBS052002 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Cross Reactive Protein, ELISA Kit - MBS093489 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Cross Reactive Protein, ELISA Kit - MBS102211 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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