ISG15

Gene Symbol	ISG15
Entrez Gene	9636
Alt Symbol	G1P2, IFI15, IMD38, IP17, UCRP, hUCRP
Species	Human
Gene Type	protein-coding
Description	ISG15 ubiquitin-like modifier
Other Description	interferon, alpha-inducible protein (clone IFI-15K)|interferon-induced 17-kDa/15-kDa protein|interferon-stimulated protein, 15 kDa|ubiquitin cross-reactive protein|ubiquitin-like protein ISG15
Swissprots	Q7Z2G2 P05161 Q96GF0 Q5SVA4
Accessions	AAA36128 EAW56295 P05161 AY168648 AAN86983 BC009507 AAH09507 BM712238 BT007297 AAP35961 BU161226 DQ892714 ABM83640 EU176738 ABW03539 M13755 AAA36038 NM_005101 NP_005092
Function	Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation- inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA- induced JNK signaling. Exhibits antiviral activity towards
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:22859821}. Secreted {ECO:0000269|PubMed:22859821}. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins.
Tissue Specificity	Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. Expressed in neutrophils, monocytes and lymphocytes. Enhanced expression seen in pancreatic adenocarcinoma, endometrial cancer, and bladder cancer, as compared to non-cancerous tissue. In bladder cancer, the increase in expression exhibits a striking positive correlation with more advanced stages of the disease. {ECO:0000269|PubMed:22859821, ECO:0000269|PubMed:7490683}.
Top Pathways	RIG-I-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ISG15 full length protein - ab173044 from Abcam Category Protein Source E. coli Species Human

Human ISG15 full length protein - ab194187 from Abcam Category Protein Source Mammalian Species Human

Human ISG15 full length protein - ab78929 from Abcam Category Protein Source E. coli Species Human

Human ISG15 full length protein - ab190048 from Abcam Category Protein Source E. coli Species Human

Human ISG15 full length protein - ab117165 from Abcam Category Protein Source E. coli Species Human

Human ISG15 peptide - ab39552 from Abcam Category Peptide

ISG15 peptide - ab179561 from Abcam Category Peptide

ISG15 Antibody Blocking Peptide - LS-E1033 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ISG15 Antibody Blocking Peptide - LS-E1034 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ISG15 Antibody Blocking Peptide - LS-E1035 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ISG15 Antibody Blocking Peptide - LS-E21722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ISG15/UCRP Partial Recombinant Protein - H00009636-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ISG15/UCRP Recombinant Protein - H00009636-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ISG15/UCRP Protein - NBC1-18442 from Novus Biologicals Category Protein Prices $249.00 Sizes 100 µg Source E.coli Species Human

ISG15/UCRP Peptide - P0246 from Novus Biologicals Category Peptide Species Human

ISG15/UCRP Peptide - P0245 from Novus Biologicals Category Peptide Species Human

ISG15-Antibody-Center-R87-Blocking-Peptide - BP1150c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ISG15-Antibody-C-term-Blocking-Peptide - BP1150b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ISG15-Antibody-N-term-Blocking-Peptide - BP1150a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human ISG15 Vinyl Sulfone, CF - UL-603-050 from R&D Systems Category Protein

Recombinant Human ISG15 AMC, CF - UL-553-050 from R&D Systems Category Protein Source E. coli-derived, Contains underivatized and C-terminal AMC derivatized protein, quantity is by derivatized content

Recombinant Human ISG15, CF - UL-601-500 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human HA-ISG15 Vinyl Sulfone, CF - UL-604-050 from R&D Systems Category Protein

Recombinant Human Pro-ISG15, CF - UL-615-500 from R&D Systems Category Protein

Recombinant Human GST-ISG15, CF - UL-600-500 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal GST (glutathione S-transferase) tag

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