LTA4H

Gene Symbol LTA4H
Entrez Gene 4048
Alt Symbol -
Species Human
Gene Type protein-coding
Description leukotriene A4 hydrolase
Other Description LTA-4 hydrolase|leukotriene A-4 hydrolase
Swissprots B4DNQ9 F8VV40 Q6IAT6 P09960 Q9UCT7
Accessions AAA89077 AAC24315 EAW97557 EAW97558 EAW97559 EAW97560 P09960 AB209740 BAD92977 AK293630 BAG57086 AK298017 BAG60321 AK301308 BAG62860 AK308184 AK310461 AK310522 BC032528 AAH32528 BC036555 AAH36555 BX647158 CR457068 CAG33349 DB019628 DC358373 J02959 AAA36177 J03459 AAA36176 JF432734 ADZ15951 R41544 XM_005268871 XP_005268928 XM_011538348 XP_011536650 XM_011538349 XP_011536651 NM_000895 NP_000886 NM_001256643 NP_001243572 NM_001256644 NP_001243573
Function Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}.
Subcellular Location Cytoplasm.
Tissue Specificity Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
Top Pathways Arachidonic acid metabolism

LTA4H (D-6) - sc-390567 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LTA4H (D-6): sc-390567. Western blot analysis of LTA4H expression in non-transfected: sc-110760 (A) and human LTA4H transfected: sc-115261 (B) 293 whole cell lysates.

LTA4H (E-7) - sc-514465 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LTA4H (E-7): sc-514465. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

LTA4H (C-21) - sc-23070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LTA4H (C-21): sc-23070. Western blot analysis of LTA4H expression in Jurkat (A) and A549 (B) whole cell lysates and mouse spleen tissue extract (C).

LTA4H (H-149) - sc-367021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LTA4H (H-149): sc-367021. Western blot analysis of LTA4H expression in non-transfected: sc-117752 (A) and human LTA4H transfected: sc-115261 (B) 293T whole cell lysates.

Anti-Leukotriene A4 hydrolase antibody - ab196607 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Leukotriene A4 hydrolase antibody (ab196607) at 1/500 dilutionLane 1 : 293T cell lysateLane 2 : HepG2 cell lysateLane 3 : PC3 cell lysateLane 4 : SW620 cell lysateLane 5 : BT474 cell lysateLane 6 : Romas cell lysateLane 7 : Mouse spleen lysateLane 8 : Mouse brain lysateLane 9 : Mouse bone marrow lysate

Anti-Leukotriene A4 hydrolase antibody - ab115838 from Abcam

Prices $407.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human Small Intestine (formalin-fixed, paraffin-embedded) tissue stained with ab115838 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Leukotriene A4 hydrolase antibody - ab86760 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Leukotriene A4 hydrolase antibody (ab86760) at 1 µg/ml (5% skim milk/ PBS buffer) + 293T cell lysate at 10 µg with gel concentration: 12%SecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Leukotriene A4 hydrolase antibody - ab23677 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Leukotriene A4 hydrolase antibody (ab23677) at 2 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-Leukotriene A4 hydrolase antibody [9C5] - ab118018 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9C5
All lanes : Anti-Leukotriene A4 hydrolase antibody [9C5] (ab118018) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Leukotriene A4 hydrolase cDNALysates/proteins at 5 µg per lane.

Anti-Leukotriene A4 hydrolase antibody [EPR5712] - ab109434 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5712
All lanes : Anti-Leukotriene A4 hydrolase antibody [EPR5712] (ab109434) at 1/10000 dilutionLane 1 : HeLa cell lysate Lane 2 : 293T cell lysateLane 3 : T47D cell lysateLane 4 : A549 cell lysateLysates/proteins at 10 µg per lane.

Anti-Leukotriene A4 hydrolase antibody [EPR5713] - ab133512 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5713
Overlay histogram showing Jurkat cells stained with ab133512 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab133512, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in Jurkat cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-LTA4H / LTA4 Antibody (clone 6B5) - LS-C114758 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6B5
IHC of paraffin-embedded Carcinoma of prostate tissue using anti-LTA4H mouse monoclonal antibody. (Dilution 1:50).

Anti-LTA4H / LTA4 Antibody (clone 9C5) - LS-C114731 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9C5
IHC of paraffin-embedded endometrium tissue using anti-LTA4H mouse monoclonal antibody. (Dilution 1:50).

Anti-LTA4H / LTA4 Antibody (clone 9G8) IHC-plus™ - LS-B10264 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 9G8
Anti-LTA4H / LTA4 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10264 concentration 10 ug/ml.

Anti-LTA4H / LTA4 Antibody - LS-C332126 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human breast cancer using LTA4H antibody at dilution of 1:100 (400x lens).

Anti-LTA4H / LTA4 Antibody (clone 3C11) - LS-C114759 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C11
IHC of paraffin-embedded Carcinoma of bladder tissue using anti-LTA4H mouse monoclonal antibody. (Dilution 1:50).

Anti-LTA4H / LTA4 Antibody (clone 5C10) - LS-C114732 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C10
IHC of paraffin-embedded pancreas tissue using anti-LTA4H mouse monoclonal antibody. (Dilution 1:50).

Anti-LTA4H / LTA4 Antibody (clone 2C5) - LS-C114757 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C5
IHC of paraffin-embedded pancreas tissue using anti-LTA4H mouse monoclonal antibody. (Dilution 1:50).

Anti-LTA4H / LTA4 Antibody (clone 2A9) - LS-C114766 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A9
IHC of paraffin-embedded prostate tissue using anti-LTA4H mouse monoclonal antibody. (Dilution 1:50).

Anti-LTA4H / LTA4 Antibody - LS-C137436 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LTA4H / LTA4 Antibody (aa101-150) - LS-C135312 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LTA4H antibody LS-C135312 Western blot of U937 cell lysate.

Anti-LTA4H / LTA4 Antibody (Internal, clone EPR5712) - LS-C138559 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5712
IHC of paraffin-embedded human breast carcinoma tissue using anti-LTA4H antibody.

Anti-LTA4H / LTA4 Antibody (Internal, clone EPR5713) - LS-C138678 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5713
IHC of paraffin-embedded human kidney tissue using anti-LTA4H antibody.

Anti-LTA4H / LTA4 Antibody IHC-plus™ - LS-B1600 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LTA4H antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1600 concentration 5 ug/ml.

Anti-LTA4H / LTA4 Antibody (aa163-191) - LS-C163913 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lymph tissue reacted with LTA4H Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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