ACACA

Gene Symbol ACACA
Entrez Gene 31
Alt Symbol ACAC, ACACAD, ACC, ACC1, ACCA
Species Human
Gene Type protein-coding
Description acetyl-CoA carboxylase alpha
Other Description ACC-alpha|acetyl-CoA carboxylase 1|acetyl-Coenzyme A carboxylase alpha
Swissprots Q86WB3 Q7Z563 Q6XDA8 Q7Z561 Q7Z564 B2RP68 Q7Z2G8 Q13085 Q86WB2 Q6KEV6
Accessions AAP94113 EAW57576 EAW57577 EAW57578 EAW57579 EAW57580 EAW57581 EAW57582 EAW57583 Q13085 AB209325 BAD92562 AB371587 BAG48316 AJ534888 CAD59556 AJ534889 CAD59557 AJ564444 CAD92089 AK129523 AK295586 BAG58478 AK295735 BAG58574 AK295805 BAG58623 AK296368 BAG59043 AK301579 BAG63071 AK308905 AK309084 AK309424 AK311329 AY237919 AAP69841 AY315619 AAP94114 AY315620 AAP94115 AY315621 AAP94116 AY315622 AAP94117 AY315623 AAP94118 AY315624 AAP94119 AY315625 AAP94120 AY315626 AAP94121 AY315627 AAP94122 BC031485 AAH31485 BC041598 BC137287 AAI37288 BF154865 CF454424 U19822 AAC50139 XM_005257267 XP_005257324 XM_006721853 XP_006721916 XM_006725320 XP_006725383 XM_011524701 XP_011523003 XM_011524702 XP_011523004 XM_011524703 XP_011523005 XM_011524704 XP_011523006 XM_011546805 XP_011545107 XM_011546806 XP_011545108 XM_011546807 XP_011545109 XM_011546808 XP_011545110 XR_934449 XR_951959 NM_198834 NP_942131 NM_198836 NP_942133 NM_198837 NP_942134 NM_198838 NP_942135 NM_198839 NP_942136 NM_000664 NM_198835
Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. {ECO:0000269|PubMed:20952656}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Top Pathways Insulin signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, Fatty acid biosynthesis, Pyruvate metabolism

Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb - 11818 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7D11
Western blot analysis of extracts from SH-SY5Y cells, untreated or treated with Oligomycin #9996 (0.5 μM, 30 min), using Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb (upper) or Acetyl-CoA Carboxylase (C83B10) Rabbit mAb #3676 (lower). The phospho-specificity of the antibody was verified by λ phosphatase treatment.

Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody - 3661 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HEK293 cells, untreated or oligomycin-treated, using Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody.

Acetyl-CoA Carboxylase 1 Antibody - 4190 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with either SignalSilence ® ACC1 siRNA or SignalSilence ® ACC2 siRNA, using Acetyl-CoA Carboxylase 1 Antibody and β-Actin (13E5) Rabbit mAb #4970.

Acetyl-CoA Carboxylase Antibody - 3662 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293, HeLa, A431, NIH/3T3, L929, C6, H-4-IIE and BAEC cells, using Acetyl CoA Carboxylase Antibody.

Acetyl-CoA Carboxylase (C83B10) Rabbit mAb - 3676 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C83B10
Western blot analysis of cell extracts from various cell lines, using Acetyl-CoA Carboxylase (C83B10) Rabbit mAb.

ACCα (D-5) - sc-137104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACCα (D-5): sc-137104. Western blot analysis of ACCα expression in DU 145 (A) and Jurkat (B) whole cell lysates.

ACCα (H-76) - sc-30212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACCα (H-76): sc-30212. Western blot analysis of ACCα expression in DU 145 whole cell lysate.

ACCα (T-18) - sc-26817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACCα (T-18): sc-26817. Immunofluorescence staining of methanol-fixed DU 145 cells showing cytoplasmic localization.

p-ACCα (F-2) - sc-271965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-ACCα (F-2): sc-271965. Western blot analysis of ACCα phosphorylation in untreated (A) and lambda protein phosphatase (sc-200312A) treated (B) rat heart tissue extracts.

Anti-Acetyl Coenzyme A Carboxylase (phospho S221) antibody [EPR3143Y] - ab109540 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3143Y
All lanes : Anti-Acetyl Coenzyme A Carboxylase (phospho S221) antibody [EPR3143Y] (ab109540) at 1/5000 dilutionLane 1 : HeLa cell lysate, untreatedLane 2 : HeLa cell lysate treated with calyculin ALysates/proteins at 10 µg per lane.SecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-Acetyl Coenzyme A Carboxylase (phospho S79) antibody - ab194851 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Acetyl Coenzyme A Carboxylase (phospho S79) antibody (ab194851) at 1/500 dilutionLane 1 : 293 cell extract, untreatedLane 2 : 293 cell extract, treated with AICAR

Anti-Acetyl Coenzyme A Carboxylase (phospho S79) antibody [EP1885Y] - ab68191 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1885Y
All lanes : Anti-Acetyl Coenzyme A Carboxylase (phospho S79) antibody [EP1885Y] (ab68191) at 1/10000 dilutionLane 1 : A431 cell lysate, untreated.Lane 2 : A431 cell lysate, treated with LP.Lysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti-rabbit at 1/2000 dilution

Anti-Acetyl Coenzyme A Carboxylase (phospho S80) antibody - ab53688 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab53688 at 1/50 dilution staining Acetyl Coenzyme A Carboxylase in human skeletal muscle by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody - ab80052 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Acetyl Coenzyme A carboxylase alpha antibody - ab72046 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Acetyl Coenzyme A carboxylase alpha antibody (ab72046) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µg

Anti-Acetyl Coenzyme A carboxylase alpha antibody - ab72045 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Acetyl Coenzyme A carboxylase alpha antibody [EPR4971] - ab109368 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4971
Overlay histogram showing SH-SY5Y cells stained with ab109368 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109368, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y] - ab45174 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP687Y
Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y] (ab45174) at 1/2000 dilution + A431 cell lysate at 10 µgSecondaryGoat anti-rabbit HRP labelled, at 1/2000 dilution

Anti-Acetyl-CoA Carboxylase / ACC Antibody (aa1925-1975) IHC-plus™ - LS-B11307 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Acetyl-CoA Carboxylase / ACC antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-Acetyl-CoA Carboxylase / ACC Antibody (C-Terminus) IHC-plus™ - LS-B11308 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Acetyl-CoA Carboxylase / ACC antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-Acetyl-CoA Carboxylase / ACC Antibody (aa2009-2039) - LS-C155899 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ACACA Antibody western blot of 293 cell line lysates (35 ug/lane). The ACACA antibody detected the ACACA protein (arrow).

Anti-Acetyl-CoA Carboxylase / ACC Antibody (His74) - LS-C176257 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of ACC1 (H74) pAb in paraffin-embedded human skeletal muscle brain tissue.

Anti-Acetyl-CoA Carboxylase / ACC Antibody (clone 6H5) - LS-C196595 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6H5
Detection limit for recombinant GST tagged ACACA is approximately 0.03 ng/ml as a capture antibody.

Anti-Acetyl-CoA Carboxylase / ACC Antibody (N-Terminus, clone EPR4971) - LS-C137860 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4971
IHC of paraffin-embedded skeletal muscle tissue using anti-Acetyl CoA Carboxylase 1 (ACC1) antibody.

Anti-Acetyl-CoA Carboxylase / ACC Antibody (aa2009-2039, APC) - LS-C250618 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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