ACACA

Gene Symbol ACACA
Entrez Gene 31
Alt Symbol ACAC, ACACAD, ACC, ACC1, ACCA
Species Human
Gene Type protein-coding
Description acetyl-CoA carboxylase alpha
Other Description ACC-alpha|acetyl-CoA carboxylase 1|acetyl-Coenzyme A carboxylase alpha
Swissprots Q86WB3 Q7Z563 Q6XDA8 Q7Z561 Q7Z564 B2RP68 Q7Z2G8 Q13085 Q86WB2 Q6KEV6
Accessions AAP94113 EAW57576 EAW57577 EAW57578 EAW57579 EAW57580 EAW57581 EAW57582 EAW57583 Q13085 AB209325 BAD92562 AB371587 BAG48316 AJ534888 CAD59556 AJ534889 CAD59557 AJ564444 CAD92089 AK129523 AK295586 BAG58478 AK295735 BAG58574 AK295805 BAG58623 AK296368 BAG59043 AK301579 BAG63071 AK308905 AK309084 AK309424 AK311329 AY237919 AAP69841 AY315619 AAP94114 AY315620 AAP94115 AY315621 AAP94116 AY315622 AAP94117 AY315623 AAP94118 AY315624 AAP94119 AY315625 AAP94120 AY315626 AAP94121 AY315627 AAP94122 BC031485 AAH31485 BC041598 BC137287 AAI37288 BF154865 CF454424 U19822 AAC50139 XM_005257267 XP_005257324 XM_006721853 XP_006721916 XM_006725320 XP_006725383 XM_011524701 XP_011523003 XM_011524702 XP_011523004 XM_011524703 XP_011523005 XM_011524704 XP_011523006 XM_011546805 XP_011545107 XM_011546806 XP_011545108 XM_011546807 XP_011545109 XM_011546808 XP_011545110 XR_934449 XR_951959 NM_198834 NP_942131 NM_198836 NP_942133 NM_198837 NP_942134 NM_198838 NP_942135 NM_198839 NP_942136 NM_000664 NM_198835
Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. {ECO:0000269|PubMed:20952656}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Top Pathways Insulin signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, Fatty acid biosynthesis, Pyruvate metabolism

PathScan ® Phospho-Acetyl-CoA Carboxylase (Ser79) Sandwich ELISA Kit - 7986 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 1. Treatment of Hep G2 cells with H 2 O 2 stimulates phosphorylation of ACC at Ser79, detected by the PathScan ® Phospho-ACC (Ser79) Sandwich ELISA Kit #7986, but does not affect the levels of total ACC detected by PathScan ® Total ACC Sandwich ELISA Kit #7996. Hep G2 cells (80-90% confluent) were treated 10 mM hydrogen peroxide for 10 minutes and lysed with #7018. The absorbance readings at 450 nm are shown in the top figure, while the corresponding western blots using Acetyl-CoA Carboxylase (C83B10) Rabbit mAb #3676 (left panel) or Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody #3661 (right panel) are shown in the bottom figure.

PathScan ® Phospho-Acetyl-CoA Carboxylase (Ser79) Chemiluminescent Sandwich ELISA Kit - 12116 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 1. Relationship between protein concentration of lysates from untreated and H 2 O 2 -treated Hep G2 cells and immediate light generation with chemiluminescent substrate is shown. Hep G2 cells (80-90% confluent) were treated with H 2 O 2 (10 mM, 10 min) and lysed with PathScan ® Sandwich ELISA Lysis Buffer (1X) #7018. Graph inset corresponding to the shaded area shows high sensitivity and a linear response at the low protein concentration range.

PathScan ® Total Acetyl-CoA Carboxylase Sandwich ELISA Kit - 7996 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 2. The relationship between the protein concentration of lysates from untreated and H 2 O 2 -treated Hep G2 cells and the absorbance at 450 nm using the PathScan ® Total ACC Sandwich ELISA Kit #7996 is shown.

Mouse Acetyl-CoA Carboxylase / ACC ELISA Kit (Sandwich ELISA) - LS-F4661 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 0.117 ng/ml
Range 0.313-20 ng/ml

Mouse/Human/Rat Acetyl-CoA Carboxylase / ACC ELISA Kit (Cell-Based ELISA) - LS-F1777 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.313-20 ng/ml

Human Acetyl-CoA Carboxylase / ACC ELISA Kit (Sandwich ELISA) - LS-F9181 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 1.09 ng/ml
Range 0.313-20 ng/ml

Rat Acetyl-CoA Carboxylase / ACC ELISA Kit (Sandwich ELISA) - LS-F9853 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 1.34 ng/ml
Range 0.313-20 ng/ml

Rat Acetyl-CoA Carboxylase / ACC ELISA Kit (Sandwich ELISA) - LS-F10720 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 15.6
Range 0.313-20 ng/ml

Human ACACa ELISA Kit - abx150517 from Abbexa

Category ELISA Kit
Sensitivity 1.09 ng/ml
Range 3.125 ng/ml - 200 ng/ml

Acetyl Coenzyme A Carboxylase Alpha (ACACa), Human, ELISA Kit - SEB284Hu from ARP American Research Products

Category ELISA Kit
Prices $685.00
Sizes 96 t
Sensitivity 1.09ng/mL
Range 3.12-200ng/mL

Acetyl-CoA carboxylase 1 (ACACA), Human, ELISA Kit - CSB-EL001119HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Acetyl-CoA carboxylase 1 (ACACA), Human, ELISA Kit - E01A1169 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Acetyl-CoA carboxylase 1, ACACA, Human, ELISA Kit - E1284h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Human ACACa ELISA Kit - HA0646 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine ACACa ELISA Kit - AA0646 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Acetyl CoA carboxylase 1 (ACACA), ELISA Kit - MBS7240349 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ACC1 Colorimetric Cell-Based ELISA Kit - CB5017 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS030466 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS025350 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS751112 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS018449 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS044817 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS015125 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS750105 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Acetyl Coenzyme A Carboxylase Alpha, ELISA Kit - MBS750890 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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