ATF2

Gene Symbol ATF2
Entrez Gene 1386
Alt Symbol CRE-BP1, CREB-2, CREB2, HB16, TREB7
Species Human
Gene Type protein-coding
Description activating transcription factor 2
Other Description activating transcription factor 2 splice variant ATF2-var2|cAMP response element-binding protein CRE-BP1|cAMP responsive element binding protein 2, formerly|cAMP-dependent transcription factor ATF-2|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-2|cyclic AMP-responsive element-binding protein 2|histone acetyltransferase ATF2
Swissprots A1L3Z2 A4D7V1 D3DPE9 Q8TAR1 A4D7U5 Q53RY2 Q96JT8 P15336 Q13000 G8JLM5 A4D7U4 Q3B7B7 Q4ZFU9
Accessions AAX88876 AAY15004 EAX11109 EAX11110 EAX11111 EAX11112 EAX11113 P15336 AF283776 AI200584 AK128731 BAG54719 AL050192 AY029364 AAK55760 BC026175 AAH26175 BC107698 AAI07699 BC130335 AAI30336 BC130337 AAI30338 BX648469 DA995464 DQ003036 AAY17202 DQ003037 AAY17203 DQ003038 AAY17204 DQ003039 AAY17205 DQ003040 AAY17206 DQ003041 AAY17207 DQ003042 AAY17208 DQ003043 AAY17209 DQ003044 AAY17210 DQ003045 AAY17211 DQ003046 AAY17212 DQ003047 AAY17213 DQ003048 AAY17214 DQ003049 AAY17215 HQ258270 ADR83024 M31630 AAA35951 X15875 CAA33886 NM_001256090 NP_001243019 NM_001256091 NP_001243020 NM_001256092 NP_001243021 NM_001256093 NP_001243022 NM_001256094 NP_001243023 NM_001880 NP_001871 NR_045768 NR_045769 NR_045770 NR_045771 NR_045772 NR_045773 NR_045774
Function Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF).
Subcellular Location Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co- localizes with the MRN complex in the IR-induced foci (IRIF).
Tissue Specificity Ubiquitously expressed, with more abundant expression in the brain.
Top Pathways Estrogen signaling pathway, MAPK signaling pathway, Glucagon signaling pathway, Thyroid hormone synthesis, cGMP-PKG signaling pathway

Human Activating Transcription Factor 2 Gene - orb92467 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

Human-ATF2-cDNA-Clone - DC14609 from Abgent, a WuXi AppTec company

Prices $282.15
Sizes 10 µg
Species Human
Accession BC026175

ATF2 - MBS1277486 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC130335

ATF2 - MBS1275079 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC026175

Human ATF2 ORF Clone (BC026175) - CDCS410023 from Creative biogene

Species Human
Accession P15336

Human ATF2 ORF Clone (BC130335) - CDCS410024 from Creative biogene

Species Human
Accession P15336

Human ATF2 ORF clone (NM_001880.2) - CDCB160247 from Creative biogene

Species Human
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