PDHA1

Gene Symbol PDHA1
Entrez Gene 5160
Alt Symbol PDHA, PDHAD, PDHCE1A, PHE1A
Species Human
Gene Type protein-coding
Description pyruvate dehydrogenase (lipoamide) alpha 1
Other Description PDHE1-A type I|pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial|pyruvate dehydrogenase complex, E1-alpha polypeptide 1
Swissprots Q53H41 B7Z3T7 A5YVE9 Q9NP12 Q9UBJ8 Q5JPT8 Q9UNG5 Q9UBU0 P08559 Q9UNG4 B7Z3X5 B2R5P7
Accessions AAA31853 AAA60051 AAB32351 AAB39723 AAB39724 AAB39725 AAB39726 AAB39727 AAB39728 AAB39729 AAB39730 AAD16047 AAD23841 AAD23842 AAD23843 AAD23844 AAD23845 AAD23846 AAD23847 AAD23848 AAD23849 AAD23850 AAD23851 AAD23852 AAD23853 AAD23854 AAD23855 AAD23856 AAD23857 AAD23858 AAD23859 AAD23860 AAD23861 AAD23862 AAD23863 AAD23864 AAD23866 AAD23867 AAD23868 AAD23869 AAD23870 AAD23871 AAD23872 AAD23873 AAD23874 AAD23875 AAD23876 BAA14121 EAW98960 EAW98961 P08559 AK129887 AK222740 BAD96460 AK222988 BAD96708 AK293250 BAH11476 AK296341 BAH12323 AK296457 BAH12361 AK312263 BAG35194 AW204705 BC002406 AAH02406 BU170389 DA075402 DC361191 DQ891865 ABM82791 DQ895054 ABM85980 DQ895057 ABM85983 EF576990 ABQ58815 EF590116 EF590117 ABQ59099 J03503 AAA60055 J03575 AAA60050 L13318 AAA60227 L48690 AAB59581 M24848 AAA36533 R49470 S89908 AAB21863 X52709 CAA36933 X52710 CAA36934 XM_011545531 XP_011543833 XM_011545532 XP_011543834 NM_000284 NP_000275 NM_001173454 NP_001166925 NM_001173455 NP_001166926 NM_001173456 NP_001166927
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}.
Subcellular Location Mitochondrion matrix.
Tissue Specificity Ubiquitous.
Top Pathways Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Central carbon metabolism in cancer, Glucagon signaling pathway, Pyruvate metabolism

PDH-E1α CRISPR/Cas9 KO Plasmid (h) - sc-401044 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α HDR Plasmid (h) - sc-401044-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α Double Nickase Plasmid (h) - sc-401044-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α Double Nickase Plasmid (h2) - sc-401044-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α CRISPR Activation Plasmid (h) - sc-401044-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α CRISPR Activation Plasmid (h2) - sc-401044-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α Lentiviral Activation Particles (h) - sc-401044-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α Lentiviral Activation Particles (h2) - sc-401044-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDH-E1α siRNA (h) - sc-91064 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDH-E1α shRNA Plasmid (h) - sc-91064-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDH-E1α shRNA (h) Lentiviral Particles - sc-91064-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU142981 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN16555 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16555 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01389 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01389

PDHA1 siRNA (Human) - CRH3440 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human PDHA1 siRNA - orb263942 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PDHA1 shRNA Plasmid (Human) - CHH3440 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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