| Gene Symbol | HMGB1 |
|---|---|
| Entrez Gene | 3146 |
| Alt Symbol | HMG1, HMG3, SBP-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | high mobility group box 1 |
| Other Description | Amphoterin|HMG-1|Sulfoglucuronyl carbohydrate binding protein|high mobility group protein 1|high mobility group protein B1|high-mobility group (nonhistone chromosomal) protein 1|high-mobility group box 1 |
| Swissprots | Q14321 A5D8W9 P09429 Q6IBE1 Q5T7C3 |
| Accessions | AAB08987 AAF71287 AAK64599 ABM47301 ABS29271 EAX08457 EAX08458 EAX08459 EAX08460 EAX08461 EAX08462 P09429 AA430980 AB208998 BAD92235 AF401215 AK057120 BAG51867 AK122825 BAG53745 AK291494 BAF84183 AK304506 BAH14201 AK310975 AL110194 AX795278 CAE48262 AY377859 AAQ91389 BC003378 AAH03378 BC030981 AAH30981 BC066889 AAH66889 BC067732 AAH67732 BC140013 AAI40014 BC140018 AAI40019 BC141844 AAI41845 BT006940 AAP35586 BT020159 AAV38961 BX647267 CR456863 CAG33144 CR749614 CAH18408 D63874 BAA09924 L13804 L13805 X12597 CAA31110 XM_005266363 XP_005266420 XM_005266365 XP_005266422 XM_005266368 XP_005266425 XM_011535055 XP_011533357 XM_011535056 XP_011533358 XR_941568 NM_002128 NP_002119 |
| Function | DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Chromosome. |
| Top Pathways | Base excision repair |