LONP1

Gene Symbol LONP1
Entrez Gene 9361
Alt Symbol CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON
Species Human
Gene Type protein-coding
Description lon peptidase 1, mitochondrial
Other Description LONP|hLON ATP-dependent protease|lon protease homolog, mitochondrial|lon protease-like protein|mitochondrial ATP-dependent protease Lon|mitochondrial lon protease-like protein|serine protease 15
Swissprots Q8N8K8 P36776 B3KPH8 E5KMH8 P36777 Q9UQ95 D6W635 F5GZ27
Accessions AAD24414 ADP90374 ADP90375 ADP90376 ADP90377 ADP90378 ADP90379 ADP90380 ADP90381 ADP90382 ADP90383 ADP90384 ADP90385 ADP90386 ADP90387 ADP90388 ADP90389 ADP90390 ADP90391 ADP90392 ADP90393 ADP90394 ADP90395 ADP90396 ADP90397 ADP90398 ADP90399 ADP90400 ADP90401 ADP90402 ADP90403 ADP90404 ADP90405 ADP90406 ADP90407 ADP90408 ADP90409 ADP90410 ADP90411 ADP90412 ADP90413 EAW69151 EAW69152 EAW69153 EAW69154 P36776 AK056366 BAG51690 AK096433 BAG53290 AK096626 BAC04829 AK127867 BAG54587 AK298531 BAG60732 AK309720 AL096720 BC000235 AAH00235 BC109218 AAI09219 BC109219 BC139726 AAI39727 BI906625 DQ892955 ABM83881 DQ896202 ABM87201 U02389 AAA61616 XM_011528441 XP_011526743 NM_001276479 NP_001263408 NM_001276480 NP_001263409 NM_004793 NP_004784 NR_076392
Function ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:8248235}.
Subcellular Location Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:7961901}.
Tissue Specificity Duodenum, heart, lung and liver, but not thymus.

LONP1 (S-16) - sc-168471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-LONP1 antibody - ab103809 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LONP1 antibody (ab103809) at 5 µg/ml + Human kidney tissue lysate at 50 µg

Anti-LONP1 antibody - ab76487 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-LONP1 antibody (ab76487) at 1/500 dilution + recombinant human LONP1 fragment (the immunogen) at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

Anti-LONP1 / LON Antibody (aa389-418, AP) - LS-C262069 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody (aa389-418, Azide-free, HRP) - LS-C262073 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody (aa389-418, Biotin) - LS-C262070 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody (aa389-418, APC) - LS-C262071 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody - LS-C310888 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody (aa389-418, PE) - LS-C262074 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody (aa389-418, FITC) - LS-C262072 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody (aa661-761) - LS-C308792 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LONP1 / LON Antibody (aa389-418) - LS-C329775 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LONP1 / LON Antibody (aa389-418) IHC-plus™ - LS-B10032 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-LONP1 / LON antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10032 dilution 1:100.

LONP1 Antibody - NBP1-81734 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LONP1 Antibody [NBP1-81734] - Western blot analysis in mouse cell line NIH-3T3, rat cell line NBT-II and rat cell line pC12.

LONP1 Antibody - H00009361-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: LONP1 Antibody [H00009361-D01P] - Analysis of LONP1 expression in mouse kidney.

PIM1 Antibody - NBP1-87272 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PIM1 Antibody [NBP1-87272] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY419183)

LONP1 Antibody (3B2) - H00009361-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B2

Anti-LONP1 antibody produced in rabbit - HPA002192 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LONP1: <B>Cat. No. HPA002192</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human duodenum tissue showing strong cytoplasmic and/or membranous staining of glandular cells.

Monoclonal Anti-PRSS15 antibody produced in mouse - SAB1402466 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B2
<B>Immunoblotting</B><BR/>Monoclonal Anti-PRSS15, antibody produced in mouse, clone 3B2, purified immunoglobulin: <B>Cat. No. SAB1402466</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.22 kDa using immunogen protein lysate.

Anti-LONP1 antibody produced in rabbit - SAB1411647 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-LONP1: <B>Cat. No. SAB1411647</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~106.5 kDa using HepG2 lysate.

Mouse-Pim1-Antibody-C-term - AP14077b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Pim1 Antibody (C-term) (Cat. #AP14077b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Pim1 antibody detected the Pim1 protein (arrow).

LONP1-AntibodyCenter - AP19551c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
LONP1 Antibody (Center) (Cat. #AP19551c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LONP1 antibody detected the LONP1 protein (arrow).

LONP1 antibody - GTX51596 from GeneTex

Prices $319.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Anti-LONP1 antibody used in Immunohistochemistry. GTX51596

Mouse Pim1 Antibody - C-terminal region (OAAB10375) - OAAB10375 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

LONP1 Antibody - middle region (OAAB15092) - OAAB15092 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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