LONP1

Gene Symbol LONP1
Entrez Gene 9361
Alt Symbol CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON
Species Human
Gene Type protein-coding
Description lon peptidase 1, mitochondrial
Other Description LONP|hLON ATP-dependent protease|lon protease homolog, mitochondrial|lon protease-like protein|mitochondrial ATP-dependent protease Lon|mitochondrial lon protease-like protein|serine protease 15
Swissprots Q8N8K8 P36776 B3KPH8 E5KMH8 P36777 Q9UQ95 D6W635 F5GZ27
Accessions AAD24414 ADP90374 ADP90375 ADP90376 ADP90377 ADP90378 ADP90379 ADP90380 ADP90381 ADP90382 ADP90383 ADP90384 ADP90385 ADP90386 ADP90387 ADP90388 ADP90389 ADP90390 ADP90391 ADP90392 ADP90393 ADP90394 ADP90395 ADP90396 ADP90397 ADP90398 ADP90399 ADP90400 ADP90401 ADP90402 ADP90403 ADP90404 ADP90405 ADP90406 ADP90407 ADP90408 ADP90409 ADP90410 ADP90411 ADP90412 ADP90413 EAW69151 EAW69152 EAW69153 EAW69154 P36776 AK056366 BAG51690 AK096433 BAG53290 AK096626 BAC04829 AK127867 BAG54587 AK298531 BAG60732 AK309720 AL096720 BC000235 AAH00235 BC109218 AAI09219 BC109219 BC139726 AAI39727 BI906625 DQ892955 ABM83881 DQ896202 ABM87201 U02389 AAA61616 XM_011528441 XP_011526743 NM_001276479 NP_001263408 NM_001276480 NP_001263409 NM_004793 NP_004784 NR_076392
Function ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:8248235}.
Subcellular Location Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:7961901}.
Tissue Specificity Duodenum, heart, lung and liver, but not thymus.

LONP1 CRISPR/Cas9 KO Plasmid (h) - sc-411273 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 HDR Plasmid (h) - sc-411273-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 Double Nickase Plasmid (h) - sc-411273-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 Double Nickase Plasmid (h2) - sc-411273-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 CRISPR Activation Plasmid (h) - sc-411273-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 CRISPR Activation Plasmid (h2) - sc-411273-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 Lentiviral Activation Particles (h) - sc-411273-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 Lentiviral Activation Particles (h2) - sc-411273-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LONP1 siRNA (h) - sc-97290 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LONP1 shRNA Plasmid (h) - sc-97290-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LONP1 shRNA (h) Lentiviral Particles - sc-97290-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LONP1 RNAi - H00009361-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU072201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12630 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12630 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02374 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02374

LONP1 siRNA (Human) - CRH6197 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LONP1 (NM_004793.2) - SHH333239 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LONP1(NM_004793.2) - SHH159131 from Creative biogene

Category siRNA
Species Reactivities Human

LONP1 shRNA Plasmid (Human) - CHH6197 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LONP1 miRNA 3'UTR clone - MiUTR1H-05869 from Creative biogene

Species Reactivities Human
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