| Gene Symbol |
Traf5
|
| Entrez Gene |
22033
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 5
|
| Other Description |
-
|
| Swissprots |
P70191 Q61480
|
| Accessions |
EDL12971 P70191 AK141097 AK144694 BAE26019 BC012702 AAH12702 BC038645 BE691772 BY290436 D78141 BAA11218 D83528 BAA11942 NM_011633 NP_035763
|
| Function |
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytosol.
|
| Top Pathways |
Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection, TNF signaling pathway
|