Cops2

Gene Symbol Cops2
Entrez Gene 261736
Alt Symbol CSN2, Trip15
Species Rat
Gene Type protein-coding
Description COP9 signalosome subunit 2
Other Description COP9 (constitutive photomorphogenic) homolog, subunit 2|COP9 constitutive photomorphogenic homolog subunit 2|COP9 signalosome complex subunit 2|JAB1-containing signalosome subunit 2|SGN2|TR-interacting protein 15|TRIP-15|alien homolog|signalosome subunit 2|thyroid receptor-interacting protein 15|tyroid receptor interacting protein 15
Swissprots P61203 Q6P731
Accessions EDL80079 P61203 AB081072 BAC15575 BC061864 AAH61864 FQ210124 FQ214404 FQ227565 FQ232644 XM_006234901 XP_006234963 XM_008762146 XP_008760368 NM_153297 NP_695209
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12606288}. Nucleus {ECO:0000269|PubMed:12606288}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:12606288}.

Recombinant Rat COP9 signalosome complex subunit 2(Cops2) - CSB-YP005789RA CSB-EP005789RA CSB-BP005789RA CSB-MP005789RA from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Rat

Recombinant Rat COPS2 Protein - COPS2-1532R from Creative Biomart

Category Protein
Source Mammalian Cells
Species Rat

COP9 signalosome complex subunit 2 (Cops2), Recombinant Protein - MBS966179 from MyBioSource

Category Protein
Prices $1,220.00, $1,220.00, $1,440.00, $1,440.00, $1,980.00, $1,980.00, $2,445.00, $2,445.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Rat
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