| Gene Symbol |
Cops2
|
| Entrez Gene |
261736
|
| Alt Symbol |
CSN2, Trip15
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
COP9 signalosome subunit 2
|
| Other Description |
COP9 (constitutive photomorphogenic) homolog, subunit 2|COP9 constitutive photomorphogenic homolog subunit 2|COP9 signalosome complex subunit 2|JAB1-containing signalosome subunit 2|SGN2|TR-interacting protein 15|TRIP-15|alien homolog|signalosome subunit 2|thyroid receptor-interacting protein 15|tyroid receptor interacting protein 15
|
| Swissprots |
P61203 Q6P731
|
| Accessions |
EDL80079 P61203 AB081072 BAC15575 BC061864 AAH61864 FQ210124 FQ214404 FQ227565 FQ232644 XM_006234901 XP_006234963 XM_008762146 XP_008760368 NM_153297 NP_695209
|
| Function |
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12606288}. Nucleus {ECO:0000269|PubMed:12606288}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:12606288}.
|