| Gene Symbol |
Slc12a1
|
| Entrez Gene |
20495
|
| Alt Symbol |
AI788571, D630042G03Rik, Nkcc2, mBSC1, urehr3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 12, member 1
|
| Other Description |
BSC1|bumetanide-sensitive cotransporter type 1|bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2|kidney-specific Na-K-Cl symporter|solute carrier family 12 member 1
|
| Swissprots |
P55014 Q9Z1E0 Q91W55 O35938
|
| Accessions |
EDL28131 EDL28132 EDL28133 EDL28134 P55014 AI527944 AI875508 AK052750 AK085455 AK128928 BC016888 AAH16888 BC051100 U20973 AAC52632 U20974 AAB03495 U20975 AAC52633 U61381 AAD00091 U94518 AAB65150 NM_011389 NM_001079690 NP_001073158 NM_183354 NP_899197
|
| Function |
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Predominant in kidney. Isoform F is most highly expressed in the inner stripe of outer medulla, isoform A is most highly expressed in the outer stripe of the outer medulla, and isoform B is most highly expressed in the cortical thick ascending limb.
|