Gene Symbol | Slc12a1 |
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Entrez Gene | 20495 |
Alt Symbol | AI788571, D630042G03Rik, Nkcc2, mBSC1, urehr3 |
Species | Mouse |
Gene Type | protein-coding |
Description | solute carrier family 12, member 1 |
Other Description | BSC1|bumetanide-sensitive cotransporter type 1|bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2|kidney-specific Na-K-Cl symporter|solute carrier family 12 member 1 |
Swissprots | P55014 Q9Z1E0 Q91W55 O35938 |
Accessions | EDL28131 EDL28132 EDL28133 EDL28134 P55014 AI527944 AI875508 AK052750 AK085455 AK128928 BC016888 AAH16888 BC051100 U20973 AAC52632 U20974 AAB03495 U20975 AAC52633 U61381 AAD00091 U94518 AAB65150 NM_011389 NM_001079690 NP_001073158 NM_183354 NP_899197 |
Function | Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Predominant in kidney. Isoform F is most highly expressed in the inner stripe of outer medulla, isoform A is most highly expressed in the outer stripe of the outer medulla, and isoform B is most highly expressed in the cortical thick ascending limb. |
NKCC2 CRISPR/Cas9 KO Plasmid (m) - sc-422970 from Santa Cruz Biotechnology
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NKCC2 HDR Plasmid (m) - sc-422970-HDR from Santa Cruz Biotechnology
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NKCC2 Double Nickase Plasmid (m) - sc-422970-NIC from Santa Cruz Biotechnology
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NKCC2 Double Nickase Plasmid (m2) - sc-422970-NIC-2 from Santa Cruz Biotechnology
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NKCC2 CRISPR Activation Plasmid (m) - sc-422970-ACT from Santa Cruz Biotechnology
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NKCC2 CRISPR Activation Plasmid (m2) - sc-422970-ACT-2 from Santa Cruz Biotechnology
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NKCC2 Lentiviral Activation Particles (m) - sc-422970-LAC from Santa Cruz Biotechnology
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NKCC2 Lentiviral Activation Particles (m2) - sc-422970-LAC-2 from Santa Cruz Biotechnology
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NKCC2 siRNA (m) - sc-42518 from Santa Cruz Biotechnology
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NKCC2 shRNA Plasmid (m) - sc-42518-SH from Santa Cruz Biotechnology
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NKCC2 shRNA (m) Lentiviral Particles - sc-42518-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU087471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN41253 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41253 from Sigma-Aldrich
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SLC12A1 siRNA (Mouse) - CRM3750 from Cohesion Biosciences
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SLC12A1 - MBS8201281 from MyBioSource
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shRNA set against Mouse Slc12a1 (NM_183354.2) - SHH408304 from Creative biogene
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shRNA set against Mouse Slc12a1(NM_001079690.1) - SHR228102 from Creative biogene
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shRNA set against Mouse Slc12a1(NM_183354.2) - SHR228120 from Creative biogene
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SLC12A1 shRNA Plasmid (Mouse) - CHM3750 from Cohesion Biosciences
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SLC12A1 miRNA 3'UTR clone - MiUTR1M-10742 from Creative biogene
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SLC12A1 miRNA 3'UTR clone - MiUTR1M-10743 from Creative biogene
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