CYP2A6

Gene Symbol CYP2A6
Entrez Gene 1548
Alt Symbol CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
Species Human
Gene Type protein-coding
Description cytochrome P450, family 2, subfamily A, polypeptide 6
Other Description 1,4-cineole 2-exo-monooxygenase|coumarin 7-hydroxylase|cytochrome P450 2A6|cytochrome P450 IIA3|cytochrome P450(I)|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
Swissprots Q9H1Z7 Q16803 A7YAE5 Q4VAU0 Q4VAT9 Q9UK48 Q4VAU1 P10890 Q9UCU0 B2R7F6 P00190 P11509
Accessions AAB40518 AAG45229 ABV02584 ACK44068 EAW57012 P11509 AF182275 AAF13600 AK307740 AK309594 AK312964 BAG35803 BC096253 AAH96253 BC096254 AAH96254 BC096255 AAH96255 BC096256 AAH96256 DA641580 HQ258268 ADR83022 M33318 AAA52067 X06401 X13897 CAA32097 X13929 CAA32117 X13930 CAA32118 NM_000762 NP_000753
Function Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027, ECO:0000269|PubMed:17125252, ECO:0000269|PubMed:18779312, ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Liver. {ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
Top Pathways Chemical carcinogenesis, Caffeine metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450

Human CPA6 Gene cDNA Clone - orb142632 from Biorbyt

Prices $264.00
Sizes 10 μg
Species Human

Human-CYP2A6-cDNA-Clone - DC09068 from Abgent, a WuXi AppTec company

Prices $666.90
Sizes 10 µg
Species Human
Accession BC096253

CYP2A6 - MBS1269308 from MyBioSource

Species Human
Accession BC096253

Human CYP2A6 ORF Clone (BC096253) - CDCS405886 from Creative biogene

Species Human
Accession P11509

Human CPA6 ORF clone (BC033684) - CDCB159893 from Creative biogene

Species Human
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