CYP2A6

Gene Symbol	CYP2A6
Entrez Gene	1548
Alt Symbol	CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 2, subfamily A, polypeptide 6
Other Description	1,4-cineole 2-exo-monooxygenase|coumarin 7-hydroxylase|cytochrome P450 2A6|cytochrome P450 IIA3|cytochrome P450(I)|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
Swissprots	Q9H1Z7 Q16803 A7YAE5 Q4VAU0 Q4VAT9 Q9UK48 Q4VAU1 P10890 Q9UCU0 B2R7F6 P00190 P11509
Accessions	AAB40518 AAG45229 ABV02584 ACK44068 EAW57012 P11509 AF182275 AAF13600 AK307740 AK309594 AK312964 BAG35803 BC096253 AAH96253 BC096254 AAH96254 BC096255 AAH96255 BC096256 AAH96256 DA641580 HQ258268 ADR83022 M33318 AAA52067 X06401 X13897 CAA32097 X13929 CAA32117 X13930 CAA32118 NM_000762 NP_000753
Function	Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027, ECO:0000269|PubMed:17125252, ECO:0000269|PubMed:18779312, ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity	Liver. {ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
Top Pathways	Chemical carcinogenesis, Caffeine metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cytochrome P450 2A6 protein fragment - ab114776 from Abcam Category Protein Source Wheat germ Species Human

CPA6 / Carboxypeptidase A6 Antibody Blocking Peptide - LS-E923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CPA6 / Carboxypeptidase A6 Antibody Blocking Peptide - LS-E20952 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP2A6 Antibody Blocking Peptide - LS-E22017 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP2A6 Antibody Blocking Peptide - LS-E22018 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CPA6 Protein - H00057094-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Cytochrome P450 2A6 Protein - H00001548-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CPA6 Blocking Peptide - 33R-7743 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CYP2A6 Blocking Peptide - 33R-1182 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cytochrome P450 2A6 Blocking Peptide - abx062506 from Abbexa Category Peptide Species Human, Monkey

Cytochrome P450 2A6 Blocking Peptide - abx062091 from Abbexa Category Peptide Species Human

CYP2A6 - H00001548-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CYP2A6 - H00001548-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CYP2A6 fusion protein - ag16377 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CYP2A6 fusion protein - ag16748 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CYP2A6 - CYP2A6-27019TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CYP2A6 - CYP2A6-125H from Creative Biomart Category Protein Source baculovirus-insect cells

Recombinant Human CYP2A6, MYC/DDK-tagged - CYP2A6-126H from Creative Biomart Category Protein Source HEK293 cells Species Human

Cytochrome P450 2A6 Blocking Peptide - CBP3197 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

CYP2A6 (E131) Peptide - BS2193P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Cytochrome P450 2A6(CYP2A6) - CSB-YP006410HU CSB-EP006410HU CSB-BP006410HU CSB-MP006410HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CYP2A6 - TP322995 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Cytochrome P450 2A6 Recombinant Protein Antigen - NBP2-33485PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CYP2A6-Antibody-N-term-Blocking-Peptide - BP8724a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CPA6 Peptide, Human - M34GP03558H from Creative Peptides Category Peptide Source Synthetic. Species Human

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