ACO1

Gene Symbol ACO1
Entrez Gene 48
Alt Symbol ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
Species Human
Gene Type protein-coding
Description aconitase 1, soluble
Other Description IRE-BP 1|aconitate hydratase, cytoplasmic|citrate hydro-lyase|cytoplasmic aconitate hydratase|epididymis luminal protein 60|ferritin repressor protein|iron regulatory protein 1|iron-responsive element binding protein 1|iron-responsive element-binding protein 1
Swissprots P21399 Q14652 D3DRK7 Q5VZA7
Accessions ABF47095 EAW58549 EAW58550 EAW58551 EAW58552 P21399 AB209480 BAD92717 AF261088 AAF99681 AK057904 AK308752 BC018103 AAH18103 BP287929 BX538349 CAD98144 DA103947 DA409113 DA780353 EU794627 ACJ13681 M58510 AAA69900 Z11559 CAA77651 XM_005251476 XP_005251533 XM_011517888 XP_011516190 NM_001278352 NP_001265281 NM_002197 NP_002188
Function Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
Subcellular Location Cytoplasm.
Top Pathways Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism

IRP-1 CRISPR/Cas9 KO Plasmid (h) - sc-401817 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 HDR Plasmid (h) - sc-401817-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 Double Nickase Plasmid (h) - sc-401817-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 Double Nickase Plasmid (h2) - sc-401817-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 CRISPR Activation Plasmid (h) - sc-401817-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 CRISPR Activation Plasmid (h2) - sc-401817-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 Lentiviral Activation Particles (h) - sc-401817-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 Lentiviral Activation Particles (h2) - sc-401817-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRP-1 siRNA (h) - sc-40713 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRP-1 shRNA Plasmid (h) - sc-40713-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRP-1 shRNA (h) Lentiviral Particles - sc-40713-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU063531 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2722 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2722 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06056 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06056

ACO1 siRNA (Human) - CRH0036 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Aconitase 1 RNAi - H00000048-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ACO1 - MBS8237632 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ACO1 (NM_002197.2) - SHH230338 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ACO1(NM_002197.2) - SHG029719 from Creative biogene

Category siRNA
Species Reactivities Human

Human ACO1 siRNA - orb260538 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACO1 shRNA Plasmid (Human) - CHH0036 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ACO1 miRNA 3'UTR clone - MiUTR1H-00105 from Creative biogene

Species Reactivities Human
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