RHOA

Gene Symbol	RHOA
Entrez Gene	387
Alt Symbol	ARH12, ARHA, RHO12, RHOH12
Species	Human
Gene Type	protein-coding
Description	ras homolog family member A
Other Description	Aplysia ras-related homolog 12|h12|oncogene RHO H12|ras homolog gene family, member A|rho cDNA clone 12|small GTP binding protein RhoA|transforming protein RhoA
Swissprots	Q9UDJ0 Q53HM4 Q5U024 Q9UEJ4 P06749 P61586
Accessions	AAA67539 CAL40338 EAW64978 EAW64979 EAW64980 P61586 AF498970 AAM21117 AK130066 AK130808 AK222556 BAD96276 AK296654 BAG59251 AK307220 BC000946 AAH00946 BC001360 AAH01360 BC005976 AAH05976 BT019870 AAV38673 BX647063 CAE46190 EU831594 ACE87194 EU831679 ACE86513 L09159 AAA50612 L25080 AAC33178 LN607834 CEF49521 X05026 CAA28690 XM_011533695 XP_011531997 NM_001664 NP_001655
Function	Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membr
Subcellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex {ECO:0000269|PubMed:9635436}. Midbody. Cell projection, lamellipodium {ECO:0000250}. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner. {ECO:0000250}.
Top Pathways	cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Rap1 signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RhoA (phospho S188) peptide - ab42767 from Abcam Category Peptide Species Human

Human RhoA full length protein - ab101594 from Abcam Category Protein Source E. coli Species Human

Human RhoA full length protein - ab176631 from Abcam Category Protein Source E. coli Species Human

Human RhoA full length protein - ab91068 from Abcam Category Protein Source E. coli Species Human

Human RhoA peptide - ab101307 from Abcam Category Peptide

Human RhoA protein fragment - ab90514 from Abcam Category Protein Source E. coli Species Human

Recombinant Human RhoA Protein - H00000387-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

RhoA Partial Recombinant Protein - H00000387-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RhoA Protein - NBP1-50933 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

RHOA-Antibody-C-term-Blocking-Peptide - BP7757b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RHOA Protein (OPPA00043) - OPPA00043 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human RHOA protein - orb169192 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human ARH12 protein - orb245051 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human RhoA His tag protein - orb84259 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 50 μg, 100 μg Source Insect Species Human

RHOA Blocking Peptide - 33R-3522 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RHOA protein (His tag) - 80R-1608 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

RhoA (1-190, His-tag) - AR09789PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RhoA (1-190, His-tag) - AR09789PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RhoA - H00000387-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RhoA - H00000387-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RhoA - H00000387-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RhoA - H00000387-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RHOA, 1-190aa, Human, His tag, E.coli - 01-1889-A from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RHOA fusion protein - Ag1141 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RHOA Human - PRPS-064 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

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