GSK3A

Gene Symbol	GSK3A
Entrez Gene	2931
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	glycogen synthase kinase 3 alpha
Other Description	GSK-3 alpha|glycogen synthase kinase-3 alpha|serine/threonine-protein kinase GSK3A
Swissprots	O14959 P49840
Accessions	AAD11986 EAW57114 EAW57115 P49840 BC027984 AAH27984 BC051865 AAH51865 CR749620 CAH18414 D63424 BAA23608 DQ891014 ABM81940 DQ893329 ABM84255 DQ894195 ABM85121 DQ896624 ABM87623 L40027 AAA62432 NM_019884 NP_063937
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish
Top Pathways	Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human GSK3 alpha full length protein - ab42597 from Abcam Category Protein Prices $340.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human GSK3 alpha peptide - ab93065 from Abcam Category Peptide

Human GSK3 alpha protein fragment - ab158595 from Abcam Category Protein Source Wheat germ Species Human

GSK3A / GSK3 Alpha Antibody Blocking Peptide - LS-E3642 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSK3A / GSK3 Alpha Antibody Blocking Peptide - LS-E10579 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSK3A / GSK3 Alpha Antibody Blocking Peptide - LS-E9505 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSK-3 alpha Partial Recombinant Protein - H00002931-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GSK-3 alpha Recombinant Protein - P3866 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Recombinant Human GSK-3 alpha Protein - P4182 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Source E. coli Species Human

Recombinant Human GSK-3 alpha Protein - NBP1-99200 from Novus Biologicals Category Protein Prices $145.00 Sizes 100 µg Source E. coli Species Human

GSK-3 alpha Peptide - P3121 from Novus Biologicals Category Peptide Species Human

GSK3A-Antibody-S21-Blocking-peptide - BP8120c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GSK3-alpha-GSK3A-Antibody-C-term-Blocking-peptide - BP8120b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GSK3A; GSK3B peptide - orb219096 from Biorbyt Category Peptide Prices $306.00, $519.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

GSK3 alpha protein (GST Fusion) - 80R-2554 from Fitzgerald Category Protein Prices $195.00 Sizes 100 µg Source E.coli Species Human

GSK3A Blocking Peptide - 33R-6426 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human GSK3a Protein - abx066875 from Abbexa Category Protein Source E.coli Species Human

GSK3 alpha - H00002931-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GSK3 alpha - H00002931-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GSK3 alpha - P3866 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

GSK3 alpha - P4182 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

GSK3A fusion protein - Ag16108 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

GSK3A fusion protein - Ag4168 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

GSK3alpha, Active Human Recombinant Protein - GWB-FCAF97 from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

GSK3-alpha (Phospho-Ser21) Antibody Blocking Peptide - GWB-796EC8 from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

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