GSK3A

Gene Symbol	GSK3A
Entrez Gene	2931
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	glycogen synthase kinase 3 alpha
Other Description	GSK-3 alpha|glycogen synthase kinase-3 alpha|serine/threonine-protein kinase GSK3A
Swissprots	O14959 P49840
Accessions	AAD11986 EAW57114 EAW57115 P49840 BC027984 AAH27984 BC051865 AAH51865 CR749620 CAH18414 D63424 BAA23608 DQ891014 ABM81940 DQ893329 ABM84255 DQ894195 ABM85121 DQ896624 ABM87623 L40027 AAA62432 NM_019884 NP_063937
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish
Top Pathways	Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® GSK-3α/β siRNA - 6301 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections) Species Reactivities Human

SignalSilence ® GSK-3α siRNA I - 6312 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections) Species Reactivities Human, Monkey

SignalSilence ® GSK-3α siRNA II - 6524 from Cell Signaling Technology Category siRNA

GSK-3α CRISPR/Cas9 KO Plasmid (h) - sc-400518 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α HDR Plasmid (h) - sc-400518-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α Double Nickase Plasmid (h) - sc-400518-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α Double Nickase Plasmid (h2) - sc-400518-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α CRISPR Activation Plasmid (h) - sc-400518-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α CRISPR Activation Plasmid (h2) - sc-400518-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α Lentiviral Activation Particles (h) - sc-400518-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α Lentiviral Activation Particles (h2) - sc-400518-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GSK-3α siRNA (h) - sc-29339 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GSK-3α shRNA Plasmid (h) - sc-29339-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GSK-3α shRNA (h) Lentiviral Particles - sc-29339-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU040791 from Sigma-Aldrich Category siRNA

MISSION® siRNA - SIHK0870 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0869 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0871 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1395 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1396 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1531 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1531 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1395 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1396 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

GSK3A siRNA (Human) - CRH1980 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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