PRKACB
| Gene Symbol | PRKACB |
|---|---|
| Entrez Gene | 5567 |
| Alt Symbol | PKA C-beta, PKACB |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, cAMP-dependent, catalytic, beta |
| Other Description | cAMP-dependent protein kinase catalytic beta subunit isoform 4ab|cAMP-dependent protein kinase catalytic subunit beta|protein kinase A catalytic subunit beta |
| Swissprots | Q96B09 Q59GC0 P22694 Q5BNF3 B1APG4 Q5BNF1 Q5T1K3 Q8IZQ0 Q5BNE9 Q5BNF0 Q7Z3M1 B4DKB0 B4E2Q1 Q14VH1 Q5BNF2 Q8IYR5 Q5CZ92 |
| Accessions | AAN16454 ABG25919 EAW73247 EAW73248 EAW73249 P22694 AA761973 AB209189 BAD92426 AB451239 BAG70053 AB451364 BAG70178 AI445551 AK074904 AK091420 BAG52356 AK296482 BAG59122 AK304322 BAG65172 AK304375 BAG65213 AK314550 BAG37136 AK316115 BAH14486 AL050208 AM392526 CAL37404 AM393233 CAL38111 AM393317 CAL38195 AM393497 CAL38374 AY927364 AAX19487 AY927365 AAX19488 AY927366 AAX19489 AY927367 AAX19490 AY927368 AAX19491 BC016285 AAH16285 BC035058 AAH35058 BI598037 BM905428 BX369882 BX485407 BX537705 CAD97818 BX641026 CAE46017 BX647515 CR936631 CAI56774 DA188681 DA228647 DC322547 DC418574 EU832783 ACE87794 EU832835 ACE87846 EU832837 ACE87848 EU832842 ACE87853 GQ129231 ACT64365 GQ129233 ACT64367 GQ129248 ACT64382 GQ129404 ACT64538 HY160843 M34181 AAA60170 XM_005271015 XP_005271072 XM_005271016 XP_005271073 XM_005271017 XP_005271074 XM_005271018 XP_005271075 XM_005271019 XP_005271076 XM_005271020 XP_005271077 XM_006710758 XP_006710821 XM_011541764 XP_011540066 NM_001242857 NP_001229786 NM_001242858 NP_001229787 NM_001242859 NP_001229788 NM_001242860 NP_001229789 NM_001242861 NP_001229790 NM_001242862 NP_001229791 NM_001300915 NP_001287844 NM_001300916 NP_001287845 NM_001300917 NP_001287846 NM_002731 NP_002722 NM_182948 NP_891993 NM_207578 NP_997461 |
| Function | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Nucleus {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. {ECO:0000269|PubMed:11589697}. |
| Top Pathways | Adrenergic signaling in cardiomyocytes, Ovarian steroidogenesis, Wnt signaling pathway, Proteoglycans in cancer, Estrogen signaling pathway |
PKAβ cat siRNA (h) - sc-39158 from Santa Cruz Biotechnology
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PKAβ cat shRNA Plasmid (h) - sc-39158-SH from Santa Cruz Biotechnology
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PKAβ cat shRNA (h) Lentiviral Particles - sc-39158-V from Santa Cruz Biotechnology
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PKA C beta RNAi - H00005567-R06 from Novus Biologicals
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PKA C beta RNAi - H00005567-R05 from Novus Biologicals
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PKA C beta RNAi - H00005567-R04 from Novus Biologicals
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MISSION® esiRNA - EHU075621 from Sigma-Aldrich
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MISSION® siRNA - SIHK1792 from Sigma-Aldrich
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MISSION® siRNA - SIHK1793 from Sigma-Aldrich
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MISSION® siRNA - SIHK1791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17413 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17413 from Sigma-Aldrich
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PRKACB siRNA (Human) - CRH3739 from Cohesion Biosciences
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shRNA set against Human PRKACB (NM_182948.2) - SHH382680 from Creative biogene
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shRNA set against Human PRKACB(NM_002731.2) - SHR139800 from Creative biogene
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shRNA set against Human PRKACB(NM_207578.1) - SHR139864 from Creative biogene
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shRNA set against Human PRKACB(NM_182948.2) - SHR139882 from Creative biogene
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Human PRKACB siRNA - orb264241 from Biorbyt
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PRKACB shRNA Plasmid (Human) - CHH3739 from Cohesion Biosciences
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PRKACB miRNA 3'UTR clone - MiUTR1H-08260 from Creative biogene
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PRKACB miRNA 3'UTR clone - MiUTR1H-08261 from Creative biogene
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PRKACB miRNA 3'UTR clone - MiUTR1H-08262 from Creative biogene
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