| Gene Symbol |
Nampt
|
| Entrez Gene |
297508
|
| Alt Symbol |
Pbef, Pbef1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
nicotinamide phosphoribosyltransferase
|
| Other Description |
NAmPRTase|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1 homolog|visfatin
|
| Swissprots |
Q2VT47 Q80Z29
|
| Accessions |
EDM03273 Q80Z29 AB081730 BAC66022 AY831728 AAX49410 BC085681 AAH85681 NM_177928 NP_808789
|
| Function |
Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000250|UniProtKB:Q99KQ4}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12782293}. Cytoplasm {ECO:0000269|PubMed:12782293}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
|
| Tissue Specificity |
Expressed in various tissues. At the highest level in liver and at the second highest in heart. The amount is higher in heart than in lung. {ECO:0000269|PubMed:12782293}.
|
| Top Pathways |
Nicotinate and nicotinamide metabolism
|