Nampt
| Gene Symbol | Nampt |
|---|---|
| Entrez Gene | 297508 |
| Alt Symbol | Pbef, Pbef1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | nicotinamide phosphoribosyltransferase |
| Other Description | NAmPRTase|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1 homolog|visfatin |
| Swissprots | Q2VT47 Q80Z29 |
| Accessions | EDM03273 Q80Z29 AB081730 BAC66022 AY831728 AAX49410 BC085681 AAH85681 NM_177928 NP_808789 |
| Function | Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000250|UniProtKB:Q99KQ4}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12782293}. Cytoplasm {ECO:0000269|PubMed:12782293}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}. |
| Tissue Specificity | Expressed in various tissues. At the highest level in liver and at the second highest in heart. The amount is higher in heart than in lung. {ECO:0000269|PubMed:12782293}. |
| Top Pathways | Nicotinate and nicotinamide metabolism |
PBEF/Visfatin/NAMPT Recombinant Protein - P5147 from Novus Biologicals
|
||||||||||
PBEF/Visfatin/NAMPT Protein - NBP1-99212 from Novus Biologicals
|
||||||||||
PBEF/Visfatin/NAMPT Protein - NBP1-99637 from Novus Biologicals
|
||||||||||
Visfatin recombinant protein - GTX65474 from GeneTex
|
||||||||||
Visfatin recombinant protein - GTX65473 from GeneTex
|
||||||||||
Rat Visfatin Protein - abx069671 from Abbexa
|
||||||||||
Visfatin / NAMPT - P5147 from Acris Antibodies
|
||||||||||
Visfatin (VF), Rat - 20-6928 from ARP American Research Products
|
||||||||||
Recombinant Rat Nicotinamide Phosphoribosyltransferase - Nampt-1668R from Creative Biomart
|
||||||||||
Recombinant Rat Nicotinamide Nhosphoribosyltransferase, FLAG-tagged - Nampt-2167R from Creative Biomart
|
||||||||||
Recombinant Human NAMPT, FLAG-tagged - NAMPT-2168H from Creative Biomart
|
||||||||||
Visfatin / PBEF1 / NAMPT - ABP-121-0250 from Nordic BioSite
|
||||||||||
Visfatin / PBEF1 / NAMPT - ABP-121-021000 from Nordic BioSite
|
||||||||||
Visfatin / PBEF1 / NAMPT - ABP-121-02100 from Nordic BioSite
|
||||||||||
Visfatin / PBEF1 / NAMPT - ABP-121-0210 from Nordic BioSite
|
||||||||||
Recombinant Visfatin (VF) - RPA638Ra01 from Cloud-clone
|
||||||||||
Recombinant Rat Nicotinamide phosphoribosyltransferase(Nampt) - CSB-YP015422RA CSB-EP015422RA CSB-BP015422RA CSB-MP015422RA from Cusabio
|
||||||||||
Visfatin, rat recombinant - 4909-10 from Biovision
|
||||||||||
Visfatin, rat recombinant - 4909-1000 from Biovision
|
||||||||||
Visfatin, rat recombinant - 4909-50 from Biovision
|
||||||||||
Visfatin (VF) - RPU144353 from Biomatik
|
||||||||||
Visfatin, Recombinant Protein - MBS844921 from MyBioSource
|
||||||||||
Visfatin (VF), Recombinant Protein - MBS2011009 from MyBioSource
|
||||||||||
Recombinant Rat Visfatin - CRV119A from Cell Science
|
||||||||||
Recombinant Rat Visfatin - CRV119B from Cell Science
|