NEU1

Gene Symbol NEU1
Entrez Gene 4758
Alt Symbol NANH, NEU, SIAL1
Species Human
Gene Type protein-coding
Description sialidase 1 (lysosomal sialidase)
Other Description G9 sialidase|N-acetyl-alpha-neuraminidase 1|acetylneuraminyl hydrolase|exo-alpha-sialidase|lysosomal sialidase|sialidase-1
Swissprots Q99519
Accessions AAD21814 AAT11275 AAT11276 AAT11277 BAB63297 EAX03536 EAX03537 Q99519 AB209011 BAD92248 AF040958 AAB96774 AK290966 BAF83655 AK313006 BAG35842 BC000722 AAH00722 BC011900 AAH11900 BT007206 AAP35870 CA428930 CR456717 CAG32998 CR541916 CAG46714 DB122914 DQ890716 ABM81642 DQ892186 ABM83112 DQ893896 ABM84822 DQ895380 ABM86306 U84246 AAD09239 X78687 CAA55356 NM_000434 NP_000425
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:8985184}.
Subcellular Location Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Tissue Specificity Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain. {ECO:0000269|PubMed:8985184, ECO:0000269|PubMed:9054950}.
Top Pathways Lysosome, Sphingolipid metabolism, Other glycan degradation

Neu1 (F-8) - sc-166824 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neu1 (F-8): sc-166824. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Neu1 (C-20) - sc-25907 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Neu1 (H-300) - sc-32936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neu1 (H-300): sc-32936. Western blot analysis of Neu1 expression in Hep G2 whole cell lysate.

Neu1 (N-20) - sc-25905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Neu1 (V-20) - sc-25906 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Neuraminidase antibody - ab64750 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed and paraffin embedded brain (cerebellum) tissue using ab64750 at 1/500 dilution

Anti-Neuraminidase antibody - ab98178 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-Neuraminidase antibody (ab98178) at 1/250 dilution + Heart (Human) Tissue Lysate - adult normal tissue (ab29431) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Neuraminidase antibody - ab156246 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Neuraminidase antibody (ab156246) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-Neuraminidase antibody [3H4] - ab157251 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H4
All lanes : Anti-Neuraminidase antibody [3H4] (ab157251) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY Neuraminidase cDNALysates/proteins at 5 µg per lane.

Anti-Neuraminidase antibody [EPR15712] - ab197020 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15712
All lanes : Anti-Neuraminidase antibody [EPR15712] (ab197020) at 1/2000 dilutionLane 1 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysateLane 2 : Human fetal liver lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-NEU1 / NEU Antibody (aa46-415, clone 1D4B) - LS-C189821 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D4B

Anti-NEU1 / NEU Antibody (aa188-214, AP) - LS-C264225 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEU1 / NEU Antibody (aa188-214, APC) - LS-C264228 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEU1 / NEU Antibody (aa188-214, Biotin) - LS-C264230 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEU1 / NEU Antibody (aa188-214, FITC) - LS-C264231 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEU1 / NEU Antibody (aa188-214, PE) - LS-C264232 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEU1 / NEU Antibody (aa188-214, Azide-free, HRP) - LS-C264233 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEU1 / NEU Antibody (aa188-214) - LS-C157995 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NEU1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The NEU1 antibody detected the NEU1 protein (arrow).

Anti-NEU1 / NEU Antibody (clone 3C4) - LS-C175662 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NEU1.

Anti-NEU1 / NEU Antibody (clone 3F5) - LS-C175663 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NEU1.

Anti-NEU1 / NEU Antibody (clone 3C5) - LS-C175671 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NEU1.

Anti-NEU1 / NEU Antibody (aa188-214) - LS-C323300 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEU1 / NEU Antibody (aa48-315, clone 3H4) - LS-C336379 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NEU1.

Anti-NEU1 / NEU Antibody - LS-C334624 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using NEU1 antibody.

Anti-NEU1 / NEU Antibody (aa48-315, clone 3H2) - LS-C336380 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NEU1.
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