NEU1

Gene Symbol NEU1
Entrez Gene 4758
Alt Symbol NANH, NEU, SIAL1
Species Human
Gene Type protein-coding
Description sialidase 1 (lysosomal sialidase)
Other Description G9 sialidase|N-acetyl-alpha-neuraminidase 1|acetylneuraminyl hydrolase|exo-alpha-sialidase|lysosomal sialidase|sialidase-1
Swissprots Q99519
Accessions AAD21814 AAT11275 AAT11276 AAT11277 BAB63297 EAX03536 EAX03537 Q99519 AB209011 BAD92248 AF040958 AAB96774 AK290966 BAF83655 AK313006 BAG35842 BC000722 AAH00722 BC011900 AAH11900 BT007206 AAP35870 CA428930 CR456717 CAG32998 CR541916 CAG46714 DB122914 DQ890716 ABM81642 DQ892186 ABM83112 DQ893896 ABM84822 DQ895380 ABM86306 U84246 AAD09239 X78687 CAA55356 NM_000434 NP_000425
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:8985184}.
Subcellular Location Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Tissue Specificity Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain. {ECO:0000269|PubMed:8985184, ECO:0000269|PubMed:9054950}.
Top Pathways Lysosome, Sphingolipid metabolism, Other glycan degradation

Neu1 CRISPR/Cas9 KO Plasmid (h) - sc-401488 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 HDR Plasmid (h) - sc-401488-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 Double Nickase Plasmid (h) - sc-401488-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 Double Nickase Plasmid (h2) - sc-401488-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 CRISPR Activation Plasmid (h) - sc-401488-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 CRISPR Activation Plasmid (h2) - sc-401488-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 Lentiviral Activation Particles (h) - sc-401488-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 Lentiviral Activation Particles (h2) - sc-401488-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 siRNA (h) - sc-106297 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Neu1 shRNA Plasmid (h) - sc-106297-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Neu1 shRNA (h) Lentiviral Particles - sc-106297-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEU-1/Sialidase-1 RNAi - H00004758-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU104921 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15215 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15215 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05148 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05148

NEU1 siRNA (Human) - CRH3158 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Neu1 CRISPR/Cas9 KO Plasmid (h2) - sc-401488-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neu1 HDR Plasmid (h2) - sc-401488-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human NEU1 (NM_000434.3) - SHH351444 from Creative biogene

Category siRNA
Species Reactivities Human

NEU1 shRNA Plasmid (Human) - CHH3158 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NEU1 miRNA 3'UTR clone - MiUTR1H-06724 from Creative biogene

Species Reactivities Human
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