USP1

Gene Symbol	USP1
Entrez Gene	7398
Alt Symbol	UBP
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 1
Other Description	deubiquitinating enzyme 1|hUBP|ubiquitin carboxyl terminal hydrolase 1|ubiquitin carboxyl-terminal hydrolase 1|ubiquitin specific processing protease 1|ubiquitin specific protease 1|ubiquitin thioesterase 1|ubiquitin thiolesterase 1|ubiquitin-specific-processing protease 1
Swissprots	A0PJ95 Q05BX7 Q9UFR0 Q59H66 D3DQ57 O94782 Q9UNJ3
Accessions	EAX06585 EAX06586 O94782 AB014458 BAA34703 AB208893 BAD92130 AF117386 AAD11441 AK096788 AK312423 BAG35333 AL117503 CAB55967 AL117575 CAB55999 AL599240 AM392756 CAL37634 BC011881 BC018745 AAH18745 BC023216 BC032364 AAH32364 BC040140 BC050525 AAH50525 BI463072 BQ018843 BQ186837 NM_001017415 NP_001017415 NM_001017416 NP_001017416 NM_003368 NP_003359
Function	Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15694335}.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® USP1 siRNA I - 6490 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® USP1 siRNA II - 6498 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

USP1 CRISPR/Cas9 KO Plasmid (h) - sc-406837 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 HDR Plasmid (h) - sc-406837-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 Double Nickase Plasmid (h) - sc-406837-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 Double Nickase Plasmid (h2) - sc-406837-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 CRISPR Activation Plasmid (h) - sc-406837-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 CRISPR Activation Plasmid (h2) - sc-406837-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 Lentiviral Activation Particles (h) - sc-406837-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 Lentiviral Activation Particles (h2) - sc-406837-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP1 siRNA (h) - sc-88494 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP1 shRNA Plasmid (h) - sc-88494-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP1 shRNA (h) Lentiviral Particles - sc-88494-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU032301 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU037901 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22555 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22555 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07282 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07282

USP1 siRNA (Human) - CRH5059 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

USP1 - MBS8205638 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human USP1 (NM_003368.4) - SHH441200 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human USP1(NM_001017415.1) - SHL116936 from Creative biogene Category siRNA Species Reactivities Human

USP1 shRNA Plasmid (Human) - CHH5059 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

USP1 miRNA 3'UTR clone - MiUTR1H-11045 from Creative biogene Species Reactivities Human

USP1 miRNA 3'UTR clone - MiUTR3H-06004 from Creative biogene Species Reactivities Human

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