AOX1

Gene Symbol	AOX1
Entrez Gene	316
Alt Symbol	AO, AOH1
Species	Human
Gene Type	protein-coding
Description	aldehyde oxidase 1
Other Description	aldehyde oxidase|azaheterocycle hydroxylase
Swissprots	Q06278 O14765 Q9BYF0 Q53RR8 Q9UPG6 Q53TV3
Accessions	AAB83966 AAB83968 AAX93285 AAY24265 CAW36666 CAW39000 CAW41181 CAW47197 CAW63617 CAW71847 CAW80339 CAW82831 CAW86206 CAY77140 CBC02619 CBC04872 CBC06832 CBC12951 CBC45781 CBC62201 CBC79136 CBC84084 CBC89038 EAW70208 EAW70209 Q06278 AB046692 BAB40305 AK297930 BAG60247 AK301052 BAG62663 AK307738 AL079797 BC117179 AAI17180 BC117181 AAI17182 BM681054 CB153864 L11005 AAA96650 XM_011511062 XP_011509364 XR_922913 NM_001159 NP_001150
Function	Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. {ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22279051, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:22996261, ECO:0000269|PubMed:2
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:23857892}.
Tissue Specificity	Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level). {ECO:0000269|PubMed:18066686, ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:23857892, ECO:0000269|PubMed:8248161}.
Top Pathways	Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AOX1 / Aldehyde Oxidase Antibody Blocking Peptide - LS-E8396 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AOX1-Antibody-Center-Blocking-Peptide - BP6700c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Aldehyde oxidase (OPCA00007) - OPCA00007 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human AOX1 AO protein - orb244017 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Aldehyde Oxidase Blocking Peptide - abx062247 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Recombinant Aldehyde Oxidase 1 (AOX1) - RPQ195Bo01 from Uscn Life Science Inc. Category Protein Source E.coli Species Bovine

Aldehyde Oxidase Blocking Peptide - CBP1053 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

AOX1 Peptide - BS5612P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant human Aldehyde oxidase - CSB-YP001858HU CSB-BP001858HU CSB-MP001858HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Aldehyde oxidase - CSB-EP001858HU from Cusabio Category Protein Source E.coli Species Human

Aldehyde oxidase - RPC140115 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Aldehyde oxidase 1(AAO1) ,partial - MBS1265127 from MyBioSource Category Protein Prices $195.00, $465.00, $815.00, $1,290.00 Sizes 50 µg (E Coli Derived), 200 µg (E Coli Derived), 500 µg (E Coli Derived), 1 mg (E Coli Derived) Source E Coli or Yeast

Aldehyde oxidase - TP319221 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human AOX1 protein, MYC/DDK-tagged - AOX1-18H from Creative Biomart Category Protein Source HEK293 Species Human

Aldehyde Oxidase 1/AOX1 Recombinant Protein Antigen - NBP1-89071PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Aldehyde Oxidase 1/AOX1 Recombinant Protein Antigen - NBP1-89070PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AOX1 Peptide, Human - M34GP00709H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant human Aldehyde oxidase - AP70037 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Recombinant Human AOX1 Protein (236-421 aa), His-tagged - AOX1-329H from Creative Biomart Category Protein Source E. coli Species Human

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