AOX1

Gene Symbol AOX1
Entrez Gene 316
Alt Symbol AO, AOH1
Species Human
Gene Type protein-coding
Description aldehyde oxidase 1
Other Description aldehyde oxidase|azaheterocycle hydroxylase
Swissprots Q06278 O14765 Q9BYF0 Q53RR8 Q9UPG6 Q53TV3
Accessions AAB83966 AAB83968 AAX93285 AAY24265 CAW36666 CAW39000 CAW41181 CAW47197 CAW63617 CAW71847 CAW80339 CAW82831 CAW86206 CAY77140 CBC02619 CBC04872 CBC06832 CBC12951 CBC45781 CBC62201 CBC79136 CBC84084 CBC89038 EAW70208 EAW70209 Q06278 AB046692 BAB40305 AK297930 BAG60247 AK301052 BAG62663 AK307738 AL079797 BC117179 AAI17180 BC117181 AAI17182 BM681054 CB153864 L11005 AAA96650 XM_011511062 XP_011509364 XR_922913 NM_001159 NP_001150
Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. {ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22279051, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:22996261, ECO:0000269|PubMed:2
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:23857892}.
Tissue Specificity Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level). {ECO:0000269|PubMed:18066686, ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:23857892, ECO:0000269|PubMed:8248161}.
Top Pathways Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism

AOX1 CRISPR/Cas9 KO Plasmid (h) - sc-403997 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 HDR Plasmid (h) - sc-403997-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 Double Nickase Plasmid (h) - sc-403997-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 Double Nickase Plasmid (h2) - sc-403997-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 CRISPR Activation Plasmid (h) - sc-403997-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 CRISPR Activation Plasmid (h2) - sc-403997-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 Lentiviral Activation Particles (h) - sc-403997-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 Lentiviral Activation Particles (h2) - sc-403997-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AOX1 siRNA (h) - sc-94924 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AOX1 shRNA Plasmid (h) - sc-94924-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AOX1 shRNA (h) Lentiviral Particles - sc-94924-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Aldehyde Oxidase 1/AOX1 RNAi - H00000316-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU024841 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN3276 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3276 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06600 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06600

AOX1 siRNA (Human) - CRH0217 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AOX1 - MBS8202041 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Aox1 (NM_001159.3) - SHH237686 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human AOX1(NM_001159.3) - SHG062683 from Creative biogene

Category siRNA
Species Reactivities Human

Human AOX1 siRNA - orb260719 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AOX1 shRNA Plasmid (Human) - CHH0217 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AOX1 miRNA 3'UTR clone - MiUTR1H-00434 from Creative biogene

Species Reactivities Human
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