| Gene Symbol |
Rps6ka5
|
| Entrez Gene |
73086
|
| Alt Symbol |
3110005L17Rik, 6330404E13Rik, AI854034, MSK1, MSPK1, RLPK
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ribosomal protein S6 kinase, polypeptide 5
|
| Other Description |
90 kDa ribosomal protein S6 kinase 5|RLSK|RSK-like protein kinase|S6K-alpha-5|nuclear mitogen- and stress-activated protein kinase 1|ribosomal protein S6 kinase alpha-5
|
| Swissprots |
Q8C050 Q8CI92
|
| Accessions |
EDL18894 EDL18895 EDL18896 EDL18897 Q8C050 AK013999 AK018114 AK030051 AK032316 BAC27809 AK046319 AK135786 AK160758 BAE35993 AY341873 AAQ24158 AY341881 AAQ24165 BC035298 AAH35298 BC038372 XM_006516274 XP_006516337 XM_006516275 XP_006516338 XM_006516276 XP_006516339 NM_153587 NP_705815
|
| Function |
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phos
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Bladder cancer, MAPK signaling pathway, Neurotrophin signaling pathway, Circadian entrainment, TNF signaling pathway
|